%0 Journal Article
%A Pouyiourou, Maria
%A Bochtler, Tilmann
%A Coith, Cornelia
%A Wikman, Harriet
%A Kraft, Bianca
%A Hielscher, Thomas
%A Stenzinger, Albrecht
%A Riethdorf, Sabine
%A Pantel, Klaus
%A Krämer, Alwin
%T Frequency and Prognostic Value of Circulating Tumor Cells in Cancer of Unknown Primary.
%J Clinical chemistry
%V 70
%N 1
%@ 0009-9147
%C Oxford
%I Oxford University Press
%M DKFZ-2024-00058
%P 297 - 306
%D 2024
%Z #EA:A360#LA:A360#
%X Cancer of unknown primary (CUP) is defined as a primary metastatic malignancy, in which the primary tumor remains elusive in spite of a comprehensive diagnostic workup. The frequency and prognostic value of circulating tumor cells (CTCs), which are considered to be the source of metastasis, has not yet been systematically evaluated in CUP.A total of 110 patients with a confirmed diagnosis of CUP according to the European Society for Medical Oncology (ESMO) guidelines, who presented to our clinic between July 2021 and May 2023, provided blood samples for CTC quantification using CellSearch methodology. CTC counts were correlated with demographic, clinical, and molecular data generated by comprehensive genomic profiling of tumor tissue.CTCs were detected in 26
%K Humans
%K Neoplastic Cells, Circulating
%K Neoplasms, Unknown Primary: diagnosis
%K Prognosis
%K Cost of Illness
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:38175594
%R 10.1093/clinchem/hvad180
%U https://inrepo02.dkfz.de/record/286718