TY  - JOUR
AU  - Pouyiourou, Maria
AU  - Bochtler, Tilmann
AU  - Coith, Cornelia
AU  - Wikman, Harriet
AU  - Kraft, Bianca
AU  - Hielscher, Thomas
AU  - Stenzinger, Albrecht
AU  - Riethdorf, Sabine
AU  - Pantel, Klaus
AU  - Krämer, Alwin
TI  - Frequency and Prognostic Value of Circulating Tumor Cells in Cancer of Unknown Primary.
JO  - Clinical chemistry
VL  - 70
IS  - 1
SN  - 0009-9147
CY  - Oxford
PB  - Oxford University Press
M1  - DKFZ-2024-00058
SP  - 297 - 306
PY  - 2024
N1  - #EA:A360#LA:A360#
AB  - Cancer of unknown primary (CUP) is defined as a primary metastatic malignancy, in which the primary tumor remains elusive in spite of a comprehensive diagnostic workup. The frequency and prognostic value of circulating tumor cells (CTCs), which are considered to be the source of metastasis, has not yet been systematically evaluated in CUP.A total of 110 patients with a confirmed diagnosis of CUP according to the European Society for Medical Oncology (ESMO) guidelines, who presented to our clinic between July 2021 and May 2023, provided blood samples for CTC quantification using CellSearch methodology. CTC counts were correlated with demographic, clinical, and molecular data generated by comprehensive genomic profiling of tumor tissue.CTCs were detected in 26
KW  - Humans
KW  - Neoplastic Cells, Circulating
KW  - Neoplasms, Unknown Primary: diagnosis
KW  - Prognosis
KW  - Cost of Illness
LB  - PUB:(DE-HGF)16
C6  - pmid:38175594
DO  - DOI:10.1093/clinchem/hvad180
UR  - https://inrepo02.dkfz.de/record/286718
ER  -