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000286731 1001_ $$00000-0002-3844-9933$$aGhasemi, David R$$b0$$eFirst author
000286731 245__ $$aCompartments in medulloblastoma with extensive nodularity are connected through differentiation along the granular precursor lineage.
000286731 260__ $$a[London]$$bNature Publishing Group UK$$c2024
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000286731 520__ $$aMedulloblastomas with extensive nodularity are cerebellar tumors characterized by two distinct compartments and variable disease progression. The mechanisms governing the balance between proliferation and differentiation in MBEN remain poorly understood. Here, we employ a multi-modal single cell transcriptome analysis to dissect this process. In the internodular compartment, we identify proliferating cerebellar granular neuronal precursor-like malignant cells, along with stromal, vascular, and immune cells. In contrast, the nodular compartment comprises postmitotic, neuronally differentiated malignant cells. Both compartments are connected through an intermediate cell stage resembling actively migrating CGNPs. Notably, we also discover astrocytic-like malignant cells, found in proximity to migrating and differentiated cells at the transition zone between the two compartments. Our study sheds light on the spatial tissue organization and its link to the developmental trajectory, resulting in a more benign tumor phenotype. This integrative approach holds promise to explore intercompartmental interactions in other cancers with varying histology.
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000286731 7001_ $$0P:(DE-He78)34b3639de467b2c700920d7cbc3d2110$$aOkonechnikov, Konstantin$$b1$$eFirst author$$udkfz
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000286731 7001_ $$0P:(DE-He78)1670176f1912f8359289bb834eb62700$$aTirier, Stephan$$b3
000286731 7001_ $$0P:(DE-He78)5100059e746b377e2e0a37c0e24f6bf7$$aMaass, Kendra K$$b4$$udkfz
000286731 7001_ $$aSchumacher, Hanna$$b5
000286731 7001_ $$0P:(DE-He78)ee036c22158d4b18f5228616af640355$$aJoshi, Piyush$$b6$$udkfz
000286731 7001_ $$00000-0002-6814-8576$$aGold, Maxwell P$$b7
000286731 7001_ $$0P:(DE-He78)303cfc65bbd4cdc79617186d2267d9fd$$aSundheimer, Julia$$b8$$udkfz
000286731 7001_ $$0P:(DE-He78)5f5223d7faa01a1e1df8a30d85cff5b0$$aStatz, Britta$$b9
000286731 7001_ $$aRifaioglu, Ahmet S$$b10
000286731 7001_ $$0P:(DE-He78)5b10e57ed1df98e2fd31edbdeed985ba$$aBauer, Katharina$$b11$$udkfz
000286731 7001_ $$0P:(DE-He78)d70ddd73ff941566d830600443d2e69c$$aSchumacher, Sabrina$$b12$$udkfz
000286731 7001_ $$0P:(DE-He78)042bf671f0e43607f9c16be966711f16$$aBortolomeazzi, Michele$$b13$$udkfz
000286731 7001_ $$00000-0001-5382-2380$$aGiangaspero, Felice$$b14
000286731 7001_ $$0P:(DE-He78)bac03ea8237bbc7b1290321d845ddef7$$aErnst, Kati$$b15$$udkfz
000286731 7001_ $$00000-0003-4893-2184$$aClifford, Steven C$$b16
000286731 7001_ $$aSaez-Rodriguez, Julio$$b17
000286731 7001_ $$0P:(DE-He78)551bb92841f634070997aa168d818492$$aJones, David$$b18$$udkfz
000286731 7001_ $$aKawauchi, Daisuke$$b19
000286731 7001_ $$aFraenkel, Ernest$$b20
000286731 7001_ $$0P:(DE-He78)697cb039ca08f3b7e5a2a52dbf020b46$$aMallm, Jan-Philipp$$b21$$udkfz
000286731 7001_ $$0P:(DE-He78)94de5f7413279464b6e738d91dfae1eb$$aRippe, Karsten$$b22$$udkfz
000286731 7001_ $$0P:(DE-He78)8d9c904a6cea14d4c99c78ba46e41f93$$aKorshunov, Andrey$$b23$$eLast author$$udkfz
000286731 7001_ $$0P:(DE-He78)f746aa965c4e1af518b016de3aaff5d9$$aPfister, Stefan$$b24$$eLast author$$udkfz
000286731 7001_ $$0P:(DE-He78)a7c1bbac024fa232d9c6b78443328d9d$$aPajtler, Kristian$$b25$$eLast author$$udkfz
000286731 773__ $$0PERI:(DE-600)2553671-0$$a10.1038/s41467-023-44117-x$$gVol. 15, no. 1, p. 269$$n1$$p269$$tNature Communications$$v15$$x2041-1723$$y2024
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