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@ARTICLE{Ghasemi:286731,
      author       = {D. R. Ghasemi$^*$ and K. Okonechnikov$^*$ and A.
                      Rademacher$^*$ and S. Tirier$^*$ and K. K. Maass$^*$ and H.
                      Schumacher and P. Joshi$^*$ and M. P. Gold and J.
                      Sundheimer$^*$ and B. Statz$^*$ and A. S. Rifaioglu and K.
                      Bauer$^*$ and S. Schumacher$^*$ and M. Bortolomeazzi$^*$ and
                      F. Giangaspero and K. Ernst$^*$ and S. C. Clifford and J.
                      Saez-Rodriguez and D. Jones$^*$ and D. Kawauchi and E.
                      Fraenkel and J.-P. Mallm$^*$ and K. Rippe$^*$ and A.
                      Korshunov$^*$ and S. Pfister$^*$ and K. Pajtler$^*$},
      title        = {{C}ompartments in medulloblastoma with extensive nodularity
                      are connected through differentiation along the granular
                      precursor lineage.},
      journal      = {Nature Communications},
      volume       = {15},
      number       = {1},
      issn         = {2041-1723},
      address      = {[London]},
      publisher    = {Nature Publishing Group UK},
      reportid     = {DKFZ-2024-00070},
      pages        = {269},
      year         = {2024},
      note         = {#EA:B062#LA:B300#LA:B062#},
      abstract     = {Medulloblastomas with extensive nodularity are cerebellar
                      tumors characterized by two distinct compartments and
                      variable disease progression. The mechanisms governing the
                      balance between proliferation and differentiation in MBEN
                      remain poorly understood. Here, we employ a multi-modal
                      single cell transcriptome analysis to dissect this process.
                      In the internodular compartment, we identify proliferating
                      cerebellar granular neuronal precursor-like malignant cells,
                      along with stromal, vascular, and immune cells. In contrast,
                      the nodular compartment comprises postmitotic, neuronally
                      differentiated malignant cells. Both compartments are
                      connected through an intermediate cell stage resembling
                      actively migrating CGNPs. Notably, we also discover
                      astrocytic-like malignant cells, found in proximity to
                      migrating and differentiated cells at the transition zone
                      between the two compartments. Our study sheds light on the
                      spatial tissue organization and its link to the
                      developmental trajectory, resulting in a more benign tumor
                      phenotype. This integrative approach holds promise to
                      explore intercompartmental interactions in other cancers
                      with varying histology.},
      cin          = {B062 / HD01 / B360 / B066 / W192 / B300},
      ddc          = {500},
      cid          = {I:(DE-He78)B062-20160331 / I:(DE-He78)HD01-20160331 /
                      I:(DE-He78)B360-20160331 / I:(DE-He78)B066-20160331 /
                      I:(DE-He78)W192-20160331 / I:(DE-He78)B300-20160331},
      pnm          = {312 - Funktionelle und strukturelle Genomforschung
                      (POF4-312)},
      pid          = {G:(DE-HGF)POF4-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:38191550},
      doi          = {10.1038/s41467-023-44117-x},
      url          = {https://inrepo02.dkfz.de/record/286731},
}