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@ARTICLE{Lehtinen:286744,
      author       = {M. Lehtinen and L. Bruni and M. Elfström and P. Gray and
                      M. Logel and F. C. Mariz$^*$ and I. Baussano and S. Vänskä
                      and E. L. Franco and J. Dillner},
      title        = {{S}cientific approaches toward improving cervical cancer
                      elimination strategies.},
      journal      = {International journal of cancer},
      volume       = {154},
      number       = {9},
      issn         = {0020-7136},
      address      = {Bognor Regis},
      publisher    = {Wiley-Liss},
      reportid     = {DKFZ-2024-00077},
      pages        = {1537-1548},
      year         = {2024},
      note         = {2024 May 1;154(9):1537-1548},
      abstract     = {At the 2023 EUROGIN workshop scientific basis for
                      strategies to accelerate the elimination of cervical cancer
                      and its causative agent, human papillomavirus (HPV) were
                      reviewed. Although some countries have reached key
                      performance indicators toward elimination $(>90\%$ of girls
                      HPV vaccinated and $>70\%$ of women HPV screened), most are
                      yet to reach these targets, implying a need for improved
                      strategies. Gender-neutral vaccination, even with moderate
                      vaccination coverage was highlighted as a strategy to
                      achieve elimination more rapidly. It is more resilient
                      against major disturbances in vaccination delivery, such as
                      what happened during the coronavirus pandemic. Further, an
                      analysis of ethical/legal issues indicated that
                      female-restricted vaccination is problematic. Extended
                      catch-up of vaccination with concomitant screening, and
                      outreach to vulnerable groups were highlighted. Although
                      birth cohorts with high coverage of HPV vaccination at
                      school are protected against HPV, and HPVs have a very low
                      reproductive rate in women above age 35, adult women below
                      age 30 have inadequate direct protection. In addition to
                      herd protection from gender-neutral vaccination, this group
                      can be protected by offering concomitant catch-up HPV
                      vaccination and HPV screening. Furthermore, hepatitis B
                      vaccination experiences indicate that elimination cannot be
                      achieved without prioritizing vulnerable/migrant
                      populations. The long-lasting durability of
                      vaccination-induced antibody responses suggests prolonged
                      protection with HPV vaccines when adequately administrated.
                      Finally, cost-effectiveness modelling suggests that
                      high-coverage HPV vaccination in multiple population
                      segments will be resource-saving due to reduced need for
                      screening. In summary, the workshop found that strategically
                      optimal deployment of vaccination will accelerate
                      elimination of HPV and cervical cancer.},
      keywords     = {HPV (Other) / gender-neutral (Other) / population immunity
                      (Other) / screening (Other) / vaccination (Other)},
      cin          = {F035 / D335},
      ddc          = {610},
      cid          = {I:(DE-He78)F035-20160331 / I:(DE-He78)D335-20160331},
      pnm          = {314 - Immunologie und Krebs (POF4-314)},
      pid          = {G:(DE-HGF)POF4-314},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:38196123},
      doi          = {10.1002/ijc.34839},
      url          = {https://inrepo02.dkfz.de/record/286744},
}