Pre-diagnostic circulating resistin concentrations and mortality among individuals with colorectal cancer: Results from the European Prospective Investigation into Cancer and Nutrition study.

Pham, Thu Thi; Kaaks, Rudolf; Tumino, Rosario; Weiderpass, Elisabete; Nimptsch, Katharina; Wu, Kana; Chirlaque, María-Dolores; De Magistris, Maria Santucci; Jenab, Mazda; Eriksen, Anne Kirstine; Tjønneland, Anne; Pischon, Tobias; Lu, Sai San Moon; Catalano, Alberto; Sánchez, Maria-Jose; Vermeulen, Roel; Aizpurua, Amaia; Christakoudi, Sofia; Aleksandrova, Krasimira; Agnoli, Claudia; Cross, Amanda J; Katzke, Verena; Fedirko, Veronika; Severi, Gianluca; Rothwell, Joseph; Masala, Giovanna; Trobajo-Sanmartín, Camino

doi:10.1002/ijc.34830

Items
Marc 21

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024	7	_	\|a 10.1002/ijc.34830 \|2 doi
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041	_	_	\|a English
082	_	_	\|a 610
100	1	_	\|a Pham, Thu Thi \|0 0000-0002-2129-0911 \|b 0
245	_	_	\|a Pre-diagnostic circulating resistin concentrations and mortality among individuals with colorectal cancer: Results from the European Prospective Investigation into Cancer and Nutrition study.
260	_	_	\|a Bognor Regis \|c 2024 \|b Wiley-Liss
336	7	_	\|a article \|2 DRIVER
336	7	_	\|a Output Types/Journal article \|2 DataCite
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500	_	_	\|a 2024 May 1;154(9):1596-1606
520	_	_	\|a Resistin is a protein involved in inflammation and angiogenesis processes and may play a role in the progression of colorectal cancer (CRC). However, it remains unclear whether resistin is associated with increased mortality after CRC diagnosis. We examined pre-diagnostic serum resistin concentrations in relation to CRC-specific and all-cause mortality among 1343 incident CRC cases from the European Prospective Investigation into Cancer and Nutrition cohort. For CRC-specific mortality as the primary outcome, hazard ratios (HRs) and 95% confidence intervals (95% CI) were estimated from competing risk analyses based on cause-specific Cox proportional hazards models and further in sensitivity analyses using Fine-Gray proportional subdistribution hazards models. For all-cause mortality as the secondary outcome, Cox proportional hazards models were used. Subgroup analyses were performed by sex, tumor subsite, tumor stage, body mass index and time to CRC diagnosis. Resistin was measured on a median of 4.8 years before CRC diagnosis. During a median follow-up of 8.2 years, 474 deaths from CRC and 147 deaths from other causes were observed. Resistin concentrations were not associated with CRC-specific mortality (HRQ4vsQ1 = 0.95, 95% CI: 0.73-1.23; Ptrend = .97; and HRper doubling of resistin concentration = 1.00; 95% CI: 0.84-1.19; P = .98) or all-cause mortality. Results from competing risk (sensitivity) analysis were similar. No associations were found in any subgroup analyses. These findings suggest no association between pre-diagnostic circulating resistin concentrations and CRC-specific or all-cause mortality among persons with CRC, and the potential insignificance of resistin in CRC progression.
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650	_	7	\|a EPIC \|2 Other
650	_	7	\|a colorectal cancer \|2 Other
650	_	7	\|a mortality \|2 Other
650	_	7	\|a pre-diagnostic \|2 Other
650	_	7	\|a resistin \|2 Other
650	_	7	\|a survival \|2 Other
700	1	_	\|a Nimptsch, Katharina \|0 0000-0001-7877-205X \|b 1
700	1	_	\|a Aleksandrova, Krasimira \|b 2
700	1	_	\|a Jenab, Mazda \|b 3
700	1	_	\|a Fedirko, Veronika \|0 0000-0002-7805-9913 \|b 4
700	1	_	\|a Wu, Kana \|b 5
700	1	_	\|a Eriksen, Anne Kirstine \|b 6
700	1	_	\|a Tjønneland, Anne \|b 7
700	1	_	\|a Severi, Gianluca \|0 0000-0001-7157-419X \|b 8
700	1	_	\|a Rothwell, Joseph \|b 9
700	1	_	\|a Kaaks, Rudolf \|0 P:(DE-He78)4b2dc91c9d1ac33a1c0e0777d0c1697a \|b 10 \|u dkfz
700	1	_	\|a Katzke, Verena \|0 P:(DE-He78)fb68a9386399d72d84f7f34cfc6048b4 \|b 11 \|u dkfz
700	1	_	\|a Catalano, Alberto \|b 12
700	1	_	\|a Agnoli, Claudia \|b 13
700	1	_	\|a Masala, Giovanna \|b 14
700	1	_	\|a De Magistris, Maria Santucci \|b 15
700	1	_	\|a Tumino, Rosario \|b 16
700	1	_	\|a Vermeulen, Roel \|b 17
700	1	_	\|a Aizpurua, Amaia \|b 18
700	1	_	\|a Trobajo-Sanmartín, Camino \|b 19
700	1	_	\|a Chirlaque, María-Dolores \|b 20
700	1	_	\|a Sánchez, Maria-Jose \|b 21
700	1	_	\|a Lu, Sai San Moon \|b 22
700	1	_	\|a Cross, Amanda J \|b 23
700	1	_	\|a Christakoudi, Sofia \|0 0000-0001-9219-4436 \|b 24
700	1	_	\|a Weiderpass, Elisabete \|0 0000-0003-2237-0128 \|b 25
700	1	_	\|a Pischon, Tobias \|0 0000-0003-1568-767X \|b 26
773	_	_	\|a 10.1002/ijc.34830 \|g p. ijc.34830 \|0 PERI:(DE-600)1474822-8 \|n 9 \|p 1596-1606 \|t International journal of cancer \|v 154 \|y 2024 \|x 0020-7136
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Marc 21

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