%0 Journal Article
%A Penack, Olaf
%A Luft, Thomas
%A Peczynski, Christophe
%A Benner, Axel
%A Sica, Simona
%A Arat, Mutlu
%A Itäla-Remes, Maija
%A Corral, Lucia López
%A Schaap, Nicolaas P M
%A Karas, Michal
%A Raida, Ludek
%A Schroeder, Thomas
%A Dreger, Peter
%A Metafuni, Elisabetta
%A Ozcelik, Tulay
%A Sandmaier, Brenda M
%A Kordelas, Lambros
%A Moiseev, Ivan
%A Schoemans, Hélène
%A Koenecke, Christian
%A Basak, Grzegorz W
%A Peric, Zinaida
%T Endothelial Activation and Stress Index (EASIX) to predict mortality after allogeneic stem cell transplantation: a prospective study.
%J Journal for ImmunoTherapy of Cancer
%V 12
%N 1
%@ 2051-1426
%C London
%I BioMed Central
%M DKFZ-2024-00109
%P e007635
%D 2024
%X We previously reported that the 'Endothelial Activation and Stress Index' (EASIX; ((creatinine×lactate dehydrogenase)÷thrombocytes)) measured before start of conditioning predicts mortality after allogeneic hematopoietic stem cell transplantation (alloSCT) when used as continuous score. For broad clinical implementation, a prospectively validated EASIX-pre cut-off is needed that defines a high-risk cohort and is easy to use.In the current study, we first performed a retrospective cohort analysis in n=2022 alloSCT recipients and identified an optimal cut-off for predicting non-relapse mortality (NRM) as EASIX-pre=3. For cut-off validation, we conducted a multicenter prospective study with inclusion of n=317 first alloSCTs from peripheral blood stem cell in adult patients with acute leukemia, lymphoma or myelodysplastic syndrome/myeloproliferative neoplasms in the European Society for Blood and Marrow Transplantation network.Twenty-three 
%K Hematologic Neoplasms (Other)
%K Immunotherapy (Other)
%K Inflammation (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:38199608
%R 10.1136/jitc-2023-007635
%U https://inrepo02.dkfz.de/record/286992