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000286995 1001_ $$0P:(DE-He78)c67a12496b8aac150c0eef888d808d46$$aSchöttker, Ben$$b0$$eFirst author$$udkfz
000286995 245__ $$aStrong associations of serum selenoprotein P with all-cause mortality and mortality due to cancer, cardiovascular, respiratory and gastrointestinal diseases in older German adults.
000286995 260__ $$aDordrecht [u.a.]$$bSpringer Science + Business Media B.V.$$c2024
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000286995 500__ $$a#EA:C070#LA:C070#LA:C120# / 2024 Feb;39(2):121-136
000286995 520__ $$aSelenium is an essential trace mineral. The main function of selenoprotein P (SELENOP) is to transport selenium but it has also been ascribed anti-oxidative effects.To assess the association of repeated measurements of serum SELENOP concentration with all-cause and cause-specific mortality serum SELENOP was measured at baseline and 5-year follow-up in 7,186 and 4,164 participants of the ESTHER study, a German population-based cohort aged 50-74 years at baseline.During 17.3 years of follow-up, 2,126 study participants (30%) died. The relationship of serum SELENOP concentration with all-cause mortality was L-shaped, with mortality being significantly higher at SELENOP concentrations < 4.1 mg/L, which is near the bottom tertile's cut-off (4.2 mg/L). All-cause mortality of participants in the bottom SELENOP tertile was significantly increased compared to subjects in the top tertile (hazard ratio [95% confidence interval]: 1.35 [1.21-1.50]). SELENOP in the bottom tertile was further associated with increased cardiovascular mortality (1.24 [1.04-1.49]), cancer mortality (1.31 [1.09-1.58]), respiratory disease mortality (2.06 [1.28-3.32]) and gastrointestinal disease mortality (2.04 [1.25-3.32]). The excess risk of all-cause mortality for those in the bottom SELENOP tertile was more than twice as strong in men as in women (interaction of SELENOP and sex; p = 0.008).In this large cohort study, serum SELENOP concentration was inversely associated with all-cause and cause-specific mortality. Consistent inverse associations with multiple mortality outcomes might be explained by an impaired selenium transport and selenium deficiency in multiple organs. Trials testing the efficacy of selenium supplements in subjects with low baseline SELENOP concentration are needed.Retrospectively registered in the German Clinical Trials Register on Feb 14, 2018 (ID: DRKS00014028).
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000286995 650_7 $$2Other$$aAgeing
000286995 650_7 $$2Other$$aBiomarker
000286995 650_7 $$2Other$$aCohort study
000286995 650_7 $$2Other$$aMortality
000286995 650_7 $$2Other$$aSelenium
000286995 650_7 $$2Other$$aSelenoprotein P
000286995 7001_ $$aHolleczek, Bernd$$b1
000286995 7001_ $$aHybsier, Sandra$$b2
000286995 7001_ $$aKöhrle, Josef$$b3
000286995 7001_ $$aSchomburg, Lutz$$b4
000286995 7001_ $$0P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2$$aBrenner, Hermann$$b5$$eLast author$$udkfz
000286995 773__ $$0PERI:(DE-600)2004992-4$$a10.1007/s10654-023-01091-4$$n2$$p121-136$$tEuropean journal of epidemiology$$v39$$x0393-2990$$y2024
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