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@ARTICLE{Schttker:286995,
      author       = {B. Schöttker$^*$ and B. Holleczek and S. Hybsier and J.
                      Köhrle and L. Schomburg and H. Brenner$^*$},
      title        = {{S}trong associations of serum selenoprotein {P} with
                      all-cause mortality and mortality due to cancer,
                      cardiovascular, respiratory and gastrointestinal diseases in
                      older {G}erman adults.},
      journal      = {European journal of epidemiology},
      volume       = {39},
      number       = {2},
      issn         = {0393-2990},
      address      = {Dordrecht [u.a.]},
      publisher    = {Springer Science + Business Media B.V.},
      reportid     = {DKFZ-2024-00112},
      pages        = {121-136},
      year         = {2024},
      note         = {#EA:C070#LA:C070#LA:C120# / 2024 Feb;39(2):121-136},
      abstract     = {Selenium is an essential trace mineral. The main function
                      of selenoprotein P (SELENOP) is to transport selenium but it
                      has also been ascribed anti-oxidative effects.To assess the
                      association of repeated measurements of serum SELENOP
                      concentration with all-cause and cause-specific mortality
                      serum SELENOP was measured at baseline and 5-year follow-up
                      in 7,186 and 4,164 participants of the ESTHER study, a
                      German population-based cohort aged 50-74 years at
                      baseline.During 17.3 years of follow-up, 2,126 study
                      participants $(30\%)$ died. The relationship of serum
                      SELENOP concentration with all-cause mortality was L-shaped,
                      with mortality being significantly higher at SELENOP
                      concentrations < 4.1 mg/L, which is near the bottom
                      tertile's cut-off (4.2 mg/L). All-cause mortality of
                      participants in the bottom SELENOP tertile was significantly
                      increased compared to subjects in the top tertile (hazard
                      ratio $[95\%$ confidence interval]: 1.35 [1.21-1.50]).
                      SELENOP in the bottom tertile was further associated with
                      increased cardiovascular mortality (1.24 [1.04-1.49]),
                      cancer mortality (1.31 [1.09-1.58]), respiratory disease
                      mortality (2.06 [1.28-3.32]) and gastrointestinal disease
                      mortality (2.04 [1.25-3.32]). The excess risk of all-cause
                      mortality for those in the bottom SELENOP tertile was more
                      than twice as strong in men as in women (interaction of
                      SELENOP and sex; p = 0.008).In this large cohort study,
                      serum SELENOP concentration was inversely associated with
                      all-cause and cause-specific mortality. Consistent inverse
                      associations with multiple mortality outcomes might be
                      explained by an impaired selenium transport and selenium
                      deficiency in multiple organs. Trials testing the efficacy
                      of selenium supplements in subjects with low baseline
                      SELENOP concentration are needed.Retrospectively registered
                      in the German Clinical Trials Register on Feb 14, 2018 (ID:
                      DRKS00014028).},
      keywords     = {Ageing (Other) / Biomarker (Other) / Cohort study (Other) /
                      Mortality (Other) / Selenium (Other) / Selenoprotein P
                      (Other)},
      cin          = {C070 / C120},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331 / I:(DE-He78)C120-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:38198038},
      doi          = {10.1007/s10654-023-01091-4},
      url          = {https://inrepo02.dkfz.de/record/286995},
}