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| 001 | 287265 | ||
| 005 | 20250512114324.0 | ||
| 024 | 7 | _ | |a 10.1007/s11060-023-04547-5 |2 doi |
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| 024 | 7 | _ | |a 0167-594X |2 ISSN |
| 024 | 7 | _ | |a 1573-7373 |2 ISSN |
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| 041 | _ | _ | |a English |
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| 100 | 1 | _ | |a Obrecht-Sturm, Denise |0 0000-0002-3216-8452 |b 0 |
| 245 | _ | _ | |a Pineal anlage tumor: clinical and diagnostic features, and rationales for treatment. |
| 260 | _ | _ | |a Dordrecht [u.a.] |c 2024 |b Springer Science + Business Media B.V |
| 336 | 7 | _ | |a article |2 DRIVER |
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| 500 | _ | _ | |a 2024 Jan;166(2):359-368 |
| 520 | _ | _ | |a To provide a treatment-focused review and develop basic treatment guidelines for patients diagnosed with pineal anlage tumor (PAT).Prospectively collected data of three patients with pineal anlage tumor from Germany was combined with clinical details and treatment information from 17 published cases.Overall, 20 cases of PAT were identified (3 not previously reported German cases, 17 cases from published reports). Age at diagnosis ranged from 0.3 to 35.0 (median: 3.2 ± 7.8) years. All but three cases were diagnosed before the age of three years. For three cases, metastatic disease at initial staging was described. All patients underwent tumor surgery (gross-total resection: 9, subtotal resection/biopsy: 9, extent of resection unknown: 2). 15/20 patients were alive at last follow-up. Median follow-up for 10/15 surviving patients with available follow-up and treatment data was 2.4 years (0.3-6.5). Relapse was reported for 3 patients within 0.8 years after diagnosis. Five patients died, 3 after relapse and 2 from early postoperative complications. Two-year-progression-free- and -overall survival were 65.2 ± 12.7% and 49.2 ± 18.2%, respectively. All 4 patients who received intensive chemotherapy including high-dose chemotherapy combined with radiotherapy (2 focal, 2 craniospinal [CSI]) had no recurrence. Focal radiotherapy- and CSI-free survival rates in 13 evaluable patients were 46.2% (6/13) and 61.5% (8/13), respectively.PAT is an aggressive disease mostly affecting young children. Therefore, adjuvant therapy using intensive chemotherapy and considering radiotherapy appears to comprise an appropriate treatment strategy. Reporting further cases is crucial to evaluate distinct treatment strategies. |
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| 650 | _ | 7 | |a PINEAL anlage tumor |2 Other |
| 650 | _ | 7 | |a Pineal gland |2 Other |
| 650 | _ | 7 | |a Pineoblastoma |2 Other |
| 700 | 1 | _ | |a Pfaff, Elke |0 P:(DE-He78)c0538fae462bd98e3cd8d54ed885b0eb |b 1 |u dkfz |
| 700 | 1 | _ | |a Mynarek, Martin |b 2 |
| 700 | 1 | _ | |a Bison, Brigitte |b 3 |
| 700 | 1 | _ | |a Rodehüser, Martina |b 4 |
| 700 | 1 | _ | |a Becker, Martina |b 5 |
| 700 | 1 | _ | |a Kietz, Silke |b 6 |
| 700 | 1 | _ | |a Pfister, Stefan M |0 P:(DE-He78)f746aa965c4e1af518b016de3aaff5d9 |b 7 |u dkfz |
| 700 | 1 | _ | |a Jones, David T |0 P:(DE-He78)551bb92841f634070997aa168d818492 |b 8 |u dkfz |
| 700 | 1 | _ | |a Sturm, Dominik |0 P:(DE-He78)a46a5b2a871859c8e2d63d2f8c666807 |b 9 |u dkfz |
| 700 | 1 | _ | |a von Deimling, Andreas |0 P:(DE-He78)a8a10626a848d31e70cfd96a133cc144 |b 10 |u dkfz |
| 700 | 1 | _ | |a Sahm, Felix |0 P:(DE-He78)a1f4b408b9155beb2a8f7cba4d04fe88 |b 11 |u dkfz |
| 700 | 1 | _ | |a Kortmann, Rolf-Dieter |b 12 |
| 700 | 1 | _ | |a Schwarz, Rudolf |b 13 |
| 700 | 1 | _ | |a Pietsch, Torsten |b 14 |
| 700 | 1 | _ | |a Fleischhack, Gudrun |b 15 |
| 700 | 1 | _ | |a Rutkowski, Stefan |b 16 |
| 773 | _ | _ | |a 10.1007/s11060-023-04547-5 |0 PERI:(DE-600)2007293-4 |n 2 |p 359-368 |t Journal of neuro-oncology |v 166 |y 2024 |x 0167-594X |
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