%0 Journal Article
%A Gödicke, Swenja
%A Kresbach, Catena
%A Ehlert, Max
%A Obrecht, Denise
%A Altendorf, Lea
%A Hack, Karoline
%A von Hoff, Katja
%A Carén, Helena
%A Melcher, Viktoria
%A Kerl, Kornelius
%A Englinger, Bernhard
%A Filbin, Mariella
%A Pajtler, Kristian W
%A Gojo, Johannes
%A Pietsch, Torsten
%A Rutkowski, Stefan
%A Schüller, Ulrich
%T Clinically relevant molecular hallmarks of PFA ependymomas display intratumoral heterogeneity and correlate with tumor morphology.
%J Acta neuropathologica
%V 147
%N 1
%@ 0001-6322
%C Heidelberg
%I Springer
%M DKFZ-2024-00206
%P 23
%D 2024
%X Posterior fossa type A (PF-EPN-A, PFA) ependymoma are aggressive tumors that mainly affect children and have a poor prognosis. Histopathology shows significant intratumoral heterogeneity, ranging from loose tissue to often sharply demarcated, extremely cell-dense tumor areas. To determine molecular differences in morphologically different areas and to understand their clinical significance, we analyzed 113 PF-EPN-A samples, including 40 corresponding relapse samples. Cell-dense areas ranged from 0 to 100
%K Child
%K Humans
%K In Situ Hybridization, Fluorescence
%K Neoplasm Recurrence, Local
%K Ependymoma
%K Histones
%K Gene Expression Profiling
%K 1q gain (Other)
%K 6q loss (Other)
%K DNA methylation (Other)
%K Ependymoma (Other)
%K Intratumoral heterogeneity (Other)
%K Morphology (Other)
%K Histones (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:38265527
%R 10.1007/s00401-023-02682-x
%U https://inrepo02.dkfz.de/record/287281