TY  - JOUR
AU  - Gödicke, Swenja
AU  - Kresbach, Catena
AU  - Ehlert, Max
AU  - Obrecht, Denise
AU  - Altendorf, Lea
AU  - Hack, Karoline
AU  - von Hoff, Katja
AU  - Carén, Helena
AU  - Melcher, Viktoria
AU  - Kerl, Kornelius
AU  - Englinger, Bernhard
AU  - Filbin, Mariella
AU  - Pajtler, Kristian W
AU  - Gojo, Johannes
AU  - Pietsch, Torsten
AU  - Rutkowski, Stefan
AU  - Schüller, Ulrich
TI  - Clinically relevant molecular hallmarks of PFA ependymomas display intratumoral heterogeneity and correlate with tumor morphology.
JO  - Acta neuropathologica
VL  - 147
IS  - 1
SN  - 0001-6322
CY  - Heidelberg
PB  - Springer
M1  - DKFZ-2024-00206
SP  - 23
PY  - 2024
AB  - Posterior fossa type A (PF-EPN-A, PFA) ependymoma are aggressive tumors that mainly affect children and have a poor prognosis. Histopathology shows significant intratumoral heterogeneity, ranging from loose tissue to often sharply demarcated, extremely cell-dense tumor areas. To determine molecular differences in morphologically different areas and to understand their clinical significance, we analyzed 113 PF-EPN-A samples, including 40 corresponding relapse samples. Cell-dense areas ranged from 0 to 100
KW  - Child
KW  - Humans
KW  - In Situ Hybridization, Fluorescence
KW  - Neoplasm Recurrence, Local
KW  - Ependymoma
KW  - Histones
KW  - Gene Expression Profiling
KW  - 1q gain (Other)
KW  - 6q loss (Other)
KW  - DNA methylation (Other)
KW  - Ependymoma (Other)
KW  - Intratumoral heterogeneity (Other)
KW  - Morphology (Other)
KW  - Histones (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:38265527
DO  - DOI:10.1007/s00401-023-02682-x
UR  - https://inrepo02.dkfz.de/record/287281
ER  -