TY  - JOUR
AU  - Vogel, Felix Christian Eduard
AU  - Chaves-Filho, Adriano B
AU  - Schulze, Almut
TI  - Lipids as mediators of cancer progression and metastasis.
JO  - Nature cancer
VL  - 5
IS  - 1
SN  - 2662-1347
CY  - London
PB  - Nature Research
M1  - DKFZ-2024-00215
SP  - 16-29
PY  - 2024
N1  - DKFZ-ZMBH Alliance / 2024 Jan;5(1):16-29 / #EA:A410#LA:A410#
AB  - Metastasis formation is a complex process, involving multiple crucial steps, which are controlled by different regulatory mechanisms. In this context, the contribution of cancer metabolism to the metastatic cascade is being increasingly recognized. This Review focuses on changes in lipid metabolism that contribute to metastasis formation in solid tumors. We discuss the molecular mechanisms by which lipids induce a pro-metastatic phenotype and explore the role of lipids in response to oxidative stress and as signaling molecules. Finally, we reflect on potential avenues to target lipid metabolism to improve the treatment of metastatic cancers.
LB  - PUB:(DE-HGF)16
C6  - pmid:38273023
DO  - DOI:10.1038/s43018-023-00702-z
UR  - https://inrepo02.dkfz.de/record/287295
ER  -