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@ARTICLE{AlShami:287455,
      author       = {K. Al-Shami$^*$ and W. S. Ahmed and K. H. Alzoubi},
      title        = {{M}otivators and barriers towards clinical research
                      participation: {A} population-based survey from an {A}rab
                      {MENA} country.},
      journal      = {PLOS ONE},
      volume       = {17},
      number       = {6},
      issn         = {1932-6203},
      address      = {San Francisco, California, US},
      publisher    = {PLOS},
      reportid     = {DKFZ-2024-00247},
      pages        = {e0270300 -},
      year         = {2022},
      note         = {#EA:A410#},
      abstract     = {Jordan was the first Arab country to enact clinical
                      research regulations. The country has a well-flourished
                      pharmaceutical industry that leans heavily on clinical
                      research (CR) for drug development and post-marketing
                      surveillance. In this cross-sectional study, we sought to
                      assess the public's awareness and attitude towards CR as
                      well as their perceived motivators and barriers to CR
                      participation. A population-based, self-administered
                      questionnaire was distributed to the general public in
                      Jordan. Among the 1061 participants in this survey, $74\%$
                      reported being aware of CR. The majority $(70\%)$ agreed to
                      the role of CR in health promotion. Online information and
                      healthcare staff were the two main sources of CR information
                      for the participants. About $25\%$ of the participants
                      received prior invitations to participate in CR with $21\%$
                      agreeing to participate. However, most participants of the
                      current study $(63\%)$ were willing to participate in future
                      CR. Contributing to science, benefiting others, and
                      promoting one's own health were the top motivating factors
                      for participating in CR; while time constraints, fear of
                      research procedure, and lack of interest were the most cited
                      reasons for rejecting participation. Filling out
                      questionnaire surveys, donating blood samples, and
                      participating in physical examinations were the main CR
                      contributions of the participants. Nearly $31\%$ of the
                      participants believed that CR is conducted in a responsible
                      and ethical manner, while $57\%$ did not have an opinion
                      regarding the same matter. In addition, $49\%$ and $44\%$
                      were neutral with regards to the degree of harm and
                      confidentiality posed by CR. While only $27\%$ disagreed
                      that CR exposes participants to some form of harm, $48\%$
                      either strongly agreed $(15\%)$ or agreed $(33\%)$ that it
                      maintains high level of confidentiality for participants.
                      The current study provides insight into the public's
                      perception of CR in Jordan as well as its motivating factors
                      and perceived barriers towards participating in CR. We
                      envisage to utilize this insight as an aid in the design of
                      vigilant future awareness campaigns and recruitment
                      strategies.},
      keywords     = {Arabs / Attitude / Confidentiality / Cross-Sectional
                      Studies / Humans / Surveys and Questionnaires},
      cin          = {A410},
      ddc          = {610},
      cid          = {I:(DE-He78)A410-20160331},
      pnm          = {311 - Zellbiologie und Tumorbiologie (POF4-311)},
      pid          = {G:(DE-HGF)POF4-311},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:35749422},
      pmc          = {pmc:PMC9231817},
      doi          = {10.1371/journal.pone.0270300},
      url          = {https://inrepo02.dkfz.de/record/287455},
}