%0 Journal Article
%A Rontogianni, Marina O
%A Bouras, Emmanouil
%A Aglago, Elom Kouassivi
%A Freisling, Heinz
%A Murphy, Neil
%A Cotterchio, Michelle
%A Hampe, Jochen
%A Lindblom, Annika
%A Pai, Rish K
%A Pharoah, Paul D P
%A Phipps, Amanda I
%A van Duijnhoven, Franzel J B
%A Visvanathan, Kala
%A van Guelpen, Bethany
%A Li, Christopher I
%A Brenner, Hermann
%A Pellatt, Andrew J
%A Ogino, Shuji
%A Gunter, Marc J
%A Peters, Ulrike
%A Christakoudi, Sofia
%A Tsilidis, Konstantinos K
%T Allometric versus traditional body-shape indices and risk of colorectal cancer: a Mendelian randomization analysis.
%J International journal of obesity
%V 48
%N 5
%@ 0307-0565
%C Avenel, NJ
%I Nature Publ. Group
%M DKFZ-2024-00251
%P 709-716
%D 2024
%Z 2024 May;48(5):709-716
%X Traditional body-shape indices such as Waist Circumference (WC), Hip Circumference (HC), and Waist-to-Hip Ratio (WHR) are associated with colorectal cancer (CRC) risk, but are correlated with Body Mass Index (BMI), and adjustment for BMI introduces a strong correlation with height. Thus, new allometric indices have been developed, namely A Body Shape Index (ABSI), Hip Index (HI), and Waist-to-Hip Index (WHI), which are uncorrelated with weight and height; these have also been associated with CRC risk in observational studies, but information from Mendelian randomization (MR) studies is missing.We used two-sample MR to examine potential causal cancer site- and sex-specific associations of the genetically-predicted allometric body-shape indices with CRC risk, and compared them with BMI-adjusted traditional body-shape indices, and BMI. Data were obtained from UK Biobank and the GIANT consortium, and from GECCO, CORECT and CCFR consortia.WHI was positively associated with CRC in men (OR per SD: 1.20, 95
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:38297030
%R 10.1038/s41366-024-01479-6
%U https://inrepo02.dkfz.de/record/287459