TY  - JOUR
AU  - Rontogianni, Marina O
AU  - Bouras, Emmanouil
AU  - Aglago, Elom Kouassivi
AU  - Freisling, Heinz
AU  - Murphy, Neil
AU  - Cotterchio, Michelle
AU  - Hampe, Jochen
AU  - Lindblom, Annika
AU  - Pai, Rish K
AU  - Pharoah, Paul D P
AU  - Phipps, Amanda I
AU  - van Duijnhoven, Franzel J B
AU  - Visvanathan, Kala
AU  - van Guelpen, Bethany
AU  - Li, Christopher I
AU  - Brenner, Hermann
AU  - Pellatt, Andrew J
AU  - Ogino, Shuji
AU  - Gunter, Marc J
AU  - Peters, Ulrike
AU  - Christakoudi, Sofia
AU  - Tsilidis, Konstantinos K
TI  - Allometric versus traditional body-shape indices and risk of colorectal cancer: a Mendelian randomization analysis.
JO  - International journal of obesity
VL  - 48
IS  - 5
SN  - 0307-0565
CY  - Avenel, NJ
PB  - Nature Publ. Group
M1  - DKFZ-2024-00251
SP  - 709-716
PY  - 2024
N1  - 2024 May;48(5):709-716
AB  - Traditional body-shape indices such as Waist Circumference (WC), Hip Circumference (HC), and Waist-to-Hip Ratio (WHR) are associated with colorectal cancer (CRC) risk, but are correlated with Body Mass Index (BMI), and adjustment for BMI introduces a strong correlation with height. Thus, new allometric indices have been developed, namely A Body Shape Index (ABSI), Hip Index (HI), and Waist-to-Hip Index (WHI), which are uncorrelated with weight and height; these have also been associated with CRC risk in observational studies, but information from Mendelian randomization (MR) studies is missing.We used two-sample MR to examine potential causal cancer site- and sex-specific associations of the genetically-predicted allometric body-shape indices with CRC risk, and compared them with BMI-adjusted traditional body-shape indices, and BMI. Data were obtained from UK Biobank and the GIANT consortium, and from GECCO, CORECT and CCFR consortia.WHI was positively associated with CRC in men (OR per SD: 1.20, 95
LB  - PUB:(DE-HGF)16
C6  - pmid:38297030
DO  - DOI:10.1038/s41366-024-01479-6
UR  - https://inrepo02.dkfz.de/record/287459
ER  -