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@ARTICLE{Rontogianni:287459,
      author       = {M. O. Rontogianni and E. Bouras and E. K. Aglago and H.
                      Freisling and N. Murphy and M. Cotterchio and J. Hampe and
                      A. Lindblom and R. K. Pai and P. D. P. Pharoah and A. I.
                      Phipps and F. J. B. van Duijnhoven and K. Visvanathan and B.
                      van Guelpen and C. I. Li and H. Brenner$^*$ and A. J.
                      Pellatt and S. Ogino and M. J. Gunter and U. Peters and S.
                      Christakoudi and K. K. Tsilidis},
      title        = {{A}llometric versus traditional body-shape indices and risk
                      of colorectal cancer: a {M}endelian randomization analysis.},
      journal      = {International journal of obesity},
      volume       = {48},
      number       = {5},
      issn         = {0307-0565},
      address      = {Avenel, NJ},
      publisher    = {Nature Publ. Group},
      reportid     = {DKFZ-2024-00251},
      pages        = {709-716},
      year         = {2024},
      note         = {2024 May;48(5):709-716},
      abstract     = {Traditional body-shape indices such as Waist Circumference
                      (WC), Hip Circumference (HC), and Waist-to-Hip Ratio (WHR)
                      are associated with colorectal cancer (CRC) risk, but are
                      correlated with Body Mass Index (BMI), and adjustment for
                      BMI introduces a strong correlation with height. Thus, new
                      allometric indices have been developed, namely A Body Shape
                      Index (ABSI), Hip Index (HI), and Waist-to-Hip Index (WHI),
                      which are uncorrelated with weight and height; these have
                      also been associated with CRC risk in observational studies,
                      but information from Mendelian randomization (MR) studies is
                      missing.We used two-sample MR to examine potential causal
                      cancer site- and sex-specific associations of the
                      genetically-predicted allometric body-shape indices with CRC
                      risk, and compared them with BMI-adjusted traditional
                      body-shape indices, and BMI. Data were obtained from UK
                      Biobank and the GIANT consortium, and from GECCO, CORECT and
                      CCFR consortia.WHI was positively associated with CRC in men
                      (OR per SD: 1.20, $95\%$ CI: 1.03-1.39) and in women (1.15,
                      1.06-1.24), and similarly for colon and rectal cancer. ABSI
                      was positively associated with colon and rectal cancer in
                      men (1.27, 1.03-1.57; and 1.40, 1.10-1.77, respectively),
                      and with colon cancer in women (1.20, 1.07-1.35). There was
                      little evidence for association between HI and colon or
                      rectal cancer. The BMI-adjusted WHR and HC showed similar
                      associations to WHI and HI, whereas WC showed similar
                      associations to ABSI only in women.This large MR study
                      provides strong evidence for a potential causal positive
                      association of the allometric indices ABSI and WHI with CRC
                      in both sexes, thus establishing the association between
                      abdominal fat and CRC without the limitations of the
                      traditional waist size indices and independently of BMI.
                      Among the BMI-adjusted traditional indices, WHR and HC
                      provided equivalent associations with WHI and HI, while
                      differences were observed between WC and ABSI.},
      cin          = {C070 / C120 / HD01},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331 / I:(DE-He78)C120-20160331 /
                      I:(DE-He78)HD01-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:38297030},
      doi          = {10.1038/s41366-024-01479-6},
      url          = {https://inrepo02.dkfz.de/record/287459},
}