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| 024 | 7 | _ | |a 0095-9871 |2 ISSN |
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| 100 | 1 | _ | |a Chen, Li-Ju |0 P:(DE-He78)ad44271ecf6b1eec3e0d0089c66dfdbe |b 0 |e First author |u dkfz |
| 245 | _ | _ | |a The associations of serum vitamin D status and vitamin D supplements use with all-cause dementia, Alzheimer's disease, and vascular dementia: a UK Biobank based prospective cohort study. |
| 260 | _ | _ | |a Amsterdam |c 2024 |b Elsevier |
| 336 | 7 | _ | |a article |2 DRIVER |
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| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1712563182_9904 |2 PUB:(DE-HGF) |
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| 500 | _ | _ | |a #EA:C070#LA:C070# / 2024 Apr;119(4):1052-1064 |
| 520 | _ | _ | |a Prior studies on vitamin D and dementia outcomes yielded mixed results and had several important limitations.We aimed to assess the associations of both serum vitamin D status and supplementation with all-cause dementia, Alzheimer's disease (AD), and vascular dementia (VD) incidence.With a prospective cohort study design, we comprehensively assessed the associations of vitamin D and multivitamin supplementation, as well as vitamin D deficiency (25-hydroxyvitamin D (25(OH)D) <30 nmol/L), and insufficiency (25(OH)D 30-<50 nmol/L), with the 14-year incidence of all-cause dementia, AD, and VD in 269,229 participants, aged 55 to 69, from the UK Biobank.Although 5.0% reported regular vitamin D use and 19.8% reported multivitamin use, the majority of participants exhibited either vitamin D deficiency (18.3%) or insufficiency (34.0%). However, vitamin D deficiency was less prevalent among users of vitamin D (6.9%) or multivitamin preparations (9.5%) than among non-users (21.5%). Adjusted Cox regression models demonstrated 19-25% increased risk of all three dementia outcomes for those with vitamin D deficiency (hazard ratio (HR) [95% confidence interval (CI)]: 1.25 (1.16-1.34) for all-cause dementia; 1.19 [1.07-1.31] for AD; 1.24 [1.08-1.43] for VD) and 10-15% increased risk for those with vitamin D insufficiency (HR [95% CI]: 1.11 [1.05-1.18] for all-cause dementia; 1.10 [1.02-1.19] for AD; 1.15 [1.03-1.29] for VD). Regular users of vitamin D and multivitamins had 17% and 14% lower risk of AD (HR [95% CI]: 0.83 [0.71-0.98]) and VD (HR [95% CI]: 0.86 [0.75-0.98]) incidence, respectively.While our findings indicate potential benefits of vitamin D supplementation for dementia prevention, randomized controlled trials are essential for definitive evidence. |
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| 650 | _ | 7 | |a Alzheimer’s disease |2 Other |
| 650 | _ | 7 | |a Cohort study |2 Other |
| 650 | _ | 7 | |a Dementia |2 Other |
| 650 | _ | 7 | |a Vascular dementia |2 Other |
| 650 | _ | 7 | |a Vitamin D |2 Other |
| 700 | 1 | _ | |a Sha, Sha |0 P:(DE-He78)1d6f6305a65e2f7de2c7fbffbae83780 |b 1 |u dkfz |
| 700 | 1 | _ | |a Stocker, Hannah |0 P:(DE-He78)104fae0755c89365b7ae32238b3f1f52 |b 2 |u dkfz |
| 700 | 1 | _ | |a Brenner, Hermann |0 P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2 |b 3 |u dkfz |
| 700 | 1 | _ | |a Schöttker, Ben |0 P:(DE-He78)c67a12496b8aac150c0eef888d808d46 |b 4 |e Last author |u dkfz |
| 773 | _ | _ | |a 10.1016/j.ajcnut.2024.01.020 |g p. S0002916524000571 |0 PERI:(DE-600)1496439-9 |n 4 |p 1052-1064 |t The American journal of clinical nutrition |v 119 |y 2024 |x 0095-9871 |
| 856 | 4 | _ | |u https://inrepo02.dkfz.de/record/287461/files/1-s2.0-S0002916524000571-main.pdf |
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