%0 Journal Article
%A Metzner, Margareta
%A Zhevachevska, Daria
%A Schlechter, Annika
%A Kehrein, Florian
%A Schlecker, Julian
%A Murillo, Carlos
%A Brons, Stephan
%A Jaekel, Oliver
%A Martisikova, Maria
%A Gehrke, Tim
%T Energy painting: helium-beam radiography with thin detectors and multiple beam energies.
%J Physics in medicine and biology
%V 69
%@ 0031-9155
%C Bristol
%I IOP Publ.
%M DKFZ-2024-00254
%P 055002
%D 2024
%Z #EA:E040#LA:E040# / Phys. Med. Biol. 69 (2024) 055002
%X </td><td width="150">
%X #xD;Objective.Compact ion imaging systems based on thin detectors are a promising prospect for the clinical environment since they are easily integrated into the clinical workflow. Their measurement principle is based on energy deposition instead of the conventionally measured residual energy or range. Therefore, thin detectors are limited in the water-equivalent thickness range they can image with high precision. This article presents our energy painting method, which has been developed to render high precision imaging with thin detectors feasible even for objects with larger, clinically relevant WET ranges.</td><td width="150">
%X #xD;Approach. A detection system exclusively based on pixelated silicon Timepix detectors was used at the Heidelberg ion-beam therapy center to track single helium ions and measure their energy deposition behind the imaged object. Calibration curves were established for five initial beam energies to relate the measured energy deposition to water-equivalent thickness (WET). They were evaluated regarding their accuracy, precision and temporal stability. Furthermore, a 60 mm × 12 mm region of a wedge phantom was imaged quantitatively exploiting the calibrated energies and five different mono-energetic images. These mono-energetic images were combined in a pixel-by-pixel manner by averaging the WET-data weighted according to their single-ion WET precision (SIWP) and the number of contributing ions.</td><td width="150">
%X #xD;Main result.A quantitative helium-beam radiograph of the wedge phantom with an average SIWP of (1.82 ± 0.05) 
%K Timepix (Other)
%K ion imaging (Other)
%K ion-beam radiography (Other)
%K ion-beam radiotherapy (Other)
%K proton therapy (Other)
%K relative stopping power (Other)
%K silicon pixel detectors (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:38295403
%R 10.1088/1361-6560/ad247e
%U https://inrepo02.dkfz.de/record/287462