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@ARTICLE{Lim:287483,
      author       = {B. Lim$^*$ and K. Domsch and M. Mall$^*$ and I. Lohmann},
      title        = {{C}analizing cell fate by transcriptional repression.},
      journal      = {Molecular systems biology},
      volume       = {20},
      number       = {3},
      issn         = {1744-4292},
      address      = {Heidelberg},
      publisher    = {EMBO Press},
      reportid     = {DKFZ-2024-00261},
      pages        = {144-161},
      year         = {2024},
      note         = {ZMBH Alliance / #EA:A340#LA:A340# / 2024 Mar;20(3):144-161},
      abstract     = {Precision in the establishment and maintenance of cellular
                      identities is crucial for the development of multicellular
                      organisms and requires tight regulation of gene expression.
                      While extensive research has focused on understanding cell
                      type-specific gene activation, the complex mechanisms
                      underlying the transcriptional repression of alternative
                      fates are not fully understood. Here, we provide an overview
                      of the repressive mechanisms involved in cell fate
                      regulation. We discuss the molecular machinery responsible
                      for suppressing alternative fates and highlight the crucial
                      role of sequence-specific transcription factors (TFs) in
                      this process. Depletion of these TFs can result in unwanted
                      gene expression and increased cellular plasticity. We
                      suggest that these TFs recruit cell type-specific repressive
                      complexes to their cis-regulatory elements, enabling them to
                      modulate chromatin accessibility in a context-dependent
                      manner. This modulation effectively suppresses master
                      regulators of alternative fate programs and their downstream
                      targets. The modularity and dynamic behavior of these
                      repressive complexes enables a limited number of repressors
                      to canalize and maintain major and minor cell fate decisions
                      at different stages of development.},
      subtyp        = {Review Article},
      keywords     = {Alternative Fate Repression (Other) / Cell Fate Plasticity
                      (Other) / Cell Identity (Other) / Epigenetic Silencing
                      (Other) / Transcriptional Repressor (Other)},
      cin          = {A340},
      ddc          = {570},
      cid          = {I:(DE-He78)A340-20160331},
      pnm          = {311 - Zellbiologie und Tumorbiologie (POF4-311)},
      pid          = {G:(DE-HGF)POF4-311},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:38302581},
      doi          = {10.1038/s44320-024-00014-z},
      url          = {https://inrepo02.dkfz.de/record/287483},
}