000287616 001__ 287616
000287616 005__ 20250814105224.0
000287616 0247_ $$2doi$$a10.1016/j.xcrm.2024.101399
000287616 0247_ $$2pmid$$apmid:38307032
000287616 0247_ $$2altmetric$$aaltmetric:159080180
000287616 037__ $$aDKFZ-2024-00270
000287616 041__ $$aEnglish
000287616 082__ $$a610
000287616 1001_ $$aBao, Xuanwen$$b0
000287616 245__ $$aA multiomics analysis-assisted deep learning model identifies a macrophage-oriented module as a potential therapeutic target in colorectal cancer.
000287616 260__ $$aMaryland Heights, MO$$bElsevier$$c2024
000287616 3367_ $$2DRIVER$$aarticle
000287616 3367_ $$2DataCite$$aOutput Types/Journal article
000287616 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1712310317_9969
000287616 3367_ $$2BibTeX$$aARTICLE
000287616 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000287616 3367_ $$00$$2EndNote$$aJournal Article
000287616 500__ $$a2024 Feb 20;5(2):101399
000287616 520__ $$aColorectal cancer (CRC) is a common malignancy involving multiple cellular components. The CRC tumor microenvironment (TME) has been characterized well at single-cell resolution. However, a spatial interaction map of the CRC TME is still elusive. Here, we integrate multiomics analyses and establish a spatial interaction map to improve the prognosis, prediction, and therapeutic development for CRC. We construct a CRC immune module (CCIM) that comprises FOLR2+ macrophages, exhausted CD8+ T cells, tolerant CD8+ T cells, exhausted CD4+ T cells, and regulatory T cells. Multiplex immunohistochemistry is performed to depict the CCIM. Based on this, we utilize advanced deep learning technology to establish a spatial interaction map and predict chemotherapy response. CCIM-Net is constructed, which demonstrates good predictive performance for chemotherapy response in both the training and testing cohorts. Lastly, targeting FOLR2+ macrophage therapeutics is used to disrupt the immunosuppressive CCIM and enhance the chemotherapy response in vivo.
000287616 536__ $$0G:(DE-HGF)POF4-314$$a314 - Immunologie und Krebs (POF4-314)$$cPOF4-314$$fPOF IV$$x0
000287616 588__ $$aDataset connected to CrossRef, PubMed, , Journals: inrepo02.dkfz.de
000287616 650_7 $$2Other$$aFOLR2(+) macrophages
000287616 650_7 $$2Other$$aartificial intelligence
000287616 650_7 $$2Other$$acolorectal cancer
000287616 650_7 $$2Other$$aimmuno module
000287616 650_7 $$2Other$$atumor microenvironment
000287616 7001_ $$aLi, Qiong$$b1
000287616 7001_ $$aChen, Dong$$b2
000287616 7001_ $$aDai, Xiaomeng$$b3
000287616 7001_ $$aLiu, Chuan$$b4
000287616 7001_ $$aTian, Weihong$$b5
000287616 7001_ $$aZhang, Hangyu$$b6
000287616 7001_ $$aJin, Yuzhi$$b7
000287616 7001_ $$aWang, Yin$$b8
000287616 7001_ $$aCheng, Jinlin$$b9
000287616 7001_ $$aLai, Chunyu$$b10
000287616 7001_ $$aYe, Chanqi$$b11
000287616 7001_ $$aXin, Shan$$b12
000287616 7001_ $$0P:(DE-He78)128e4949aa4cb04fe109c52df0c67732$$aLi, Xin$$b13$$udkfz
000287616 7001_ $$aSu, Ge$$b14
000287616 7001_ $$aDing, Yongfeng$$b15
000287616 7001_ $$aXiong, Yangyang$$b16
000287616 7001_ $$aXie, Jindong$$b17
000287616 7001_ $$aTano, Vincent$$b18
000287616 7001_ $$aWang, Yanfang$$b19
000287616 7001_ $$aFu, Wenguang$$b20
000287616 7001_ $$aDeng, Shuiguang$$b21
000287616 7001_ $$aFang, Weijia$$b22
000287616 7001_ $$aSheng, Jianpeng$$b23
000287616 7001_ $$aRuan, Jian$$b24
000287616 7001_ $$aZhao, Peng$$b25
000287616 773__ $$0PERI:(DE-600)3019420-9$$a10.1016/j.xcrm.2024.101399$$gp. 101399 -$$n2$$p101399$$tCell reports / Medicine$$v5$$x2666-3791$$y2024
000287616 8564_ $$uhttps://inrepo02.dkfz.de/record/287616/files/1-s2.0-S2666379124000089-main.pdf
000287616 8564_ $$uhttps://inrepo02.dkfz.de/record/287616/files/1-s2.0-S2666379124000089-main.pdf?subformat=pdfa$$xpdfa
000287616 909CO $$ooai:inrepo02.dkfz.de:287616$$pVDB
000287616 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)128e4949aa4cb04fe109c52df0c67732$$aDeutsches Krebsforschungszentrum$$b13$$kDKFZ
000287616 9131_ $$0G:(DE-HGF)POF4-314$$1G:(DE-HGF)POF4-310$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lKrebsforschung$$vImmunologie und Krebs$$x0
000287616 9141_ $$y2024
000287616 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bCELL REP MED : 2022$$d2023-08-22
000287616 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2023-08-22
000287616 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2023-08-22
000287616 915__ $$0StatID:(DE-HGF)0320$$2StatID$$aDBCoverage$$bPubMed Central$$d2023-08-22
000287616 915__ $$0StatID:(DE-HGF)0501$$2StatID$$aDBCoverage$$bDOAJ Seal$$d2023-04-12T14:51:29Z
000287616 915__ $$0StatID:(DE-HGF)0500$$2StatID$$aDBCoverage$$bDOAJ$$d2023-04-12T14:51:29Z
000287616 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bDOAJ : Anonymous peer review$$d2023-04-12T14:51:29Z
000287616 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2023-08-22
000287616 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews$$d2023-08-22
000287616 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2023-08-22
000287616 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2023-08-22
000287616 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences$$d2023-08-22
000287616 915__ $$0StatID:(DE-HGF)1190$$2StatID$$aDBCoverage$$bBiological Abstracts$$d2023-08-22
000287616 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2023-08-22
000287616 915__ $$0StatID:(DE-HGF)1110$$2StatID$$aDBCoverage$$bCurrent Contents - Clinical Medicine$$d2023-08-22
000287616 915__ $$0StatID:(DE-HGF)9910$$2StatID$$aIF >= 10$$bCELL REP MED : 2022$$d2023-08-22
000287616 915__ $$0StatID:(DE-HGF)0561$$2StatID$$aArticle Processing Charges$$d2023-08-22
000287616 915__ $$0StatID:(DE-HGF)0700$$2StatID$$aFees$$d2023-08-22
000287616 9201_ $$0I:(DE-He78)F180-20160331$$kF180$$lChronische Entzündung und Krebs$$x0
000287616 9201_ $$0I:(DE-He78)D440-20160331$$kD440$$lChronische Entzündung und Krebs$$x1
000287616 980__ $$ajournal
000287616 980__ $$aVDB
000287616 980__ $$aI:(DE-He78)F180-20160331
000287616 980__ $$aI:(DE-He78)D440-20160331
000287616 980__ $$aUNRESTRICTED