TY - JOUR AU - Trkova, Katerina AU - Sumerauer, David AU - Bubenikova, Adela AU - Krskova, Lenka AU - Vicha, Ales AU - Koblizek, Miroslav AU - Zamecnik, Josef AU - Jurasek, Bruno AU - Kyncl, Martin AU - Malinova, Bela AU - Ondrova, Barbora AU - Jones, David T W AU - Sill, Martin AU - Strnadova, Martina AU - Stolova, Lucie AU - Misove, Adela AU - Benes, Vladimir AU - Zapotocky, Michal TI - Clinical and molecular study of radiation-induced gliomas. JO - Scientific reports VL - 14 IS - 1 SN - 2045-2322 CY - [London] PB - Macmillan Publishers Limited, part of Springer Nature M1 - DKFZ-2024-00295 SP - 3118 PY - 2024 AB - In this study, we provide a comprehensive clinical and molecular biological characterization of radiation-induced gliomas (RIG), including a risk assessment for developing gliomas. A cohort of 12 patients who developed RIG 9.5 years (3-31 years) after previous cranial radiotherapy for brain tumors or T-cell acute lymphoblastic leukemia was established. The derived risk of RIG development based on our consecutive cohort of 371 irradiated patients was 1.6 LB - PUB:(DE-HGF)16 C6 - pmid:38326438 DO - DOI:10.1038/s41598-024-53434-0 UR - https://inrepo02.dkfz.de/record/287652 ER -