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000287653 1001_ $$0P:(DE-He78)4eb274593fde2b15697a325349d89aa4$$aWinkler, Ivana$$b0$$eFirst author$$udkfz
000287653 245__ $$aThe cycling and aging mouse female reproductive tract at single-cell resolution.
000287653 260__ $$aNew York, NY$$bElsevier$$c2024
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000287653 520__ $$aThe female reproductive tract (FRT) undergoes extensive remodeling during reproductive cycling. This recurrent remodeling and how it shapes organ-specific aging remains poorly explored. Using single-cell and spatial transcriptomics, we systematically characterized morphological and gene expression changes occurring in ovary, oviduct, uterus, cervix, and vagina at each phase of the mouse estrous cycle, during decidualization, and into aging. These analyses reveal that fibroblasts play central-and highly organ-specific-roles in FRT remodeling by orchestrating extracellular matrix (ECM) reorganization and inflammation. Our results suggest a model wherein recurrent FRT remodeling over reproductive lifespan drives the gradual, age-related development of fibrosis and chronic inflammation. This hypothesis was directly tested using chemical ablation of cycling, which reduced fibrotic accumulation during aging. Our atlas provides extensive detail into how estrus, pregnancy, and aging shape the organs of the female reproductive tract and reveals the unexpected cost of the recurrent remodeling required for reproduction.
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000287653 650_7 $$2Other$$aaging
000287653 650_7 $$2Other$$acervix
000287653 650_7 $$2Other$$afibrosis
000287653 650_7 $$2Other$$ainflammation
000287653 650_7 $$2Other$$aovary
000287653 650_7 $$2Other$$aoviduct
000287653 650_7 $$2Other$$asingle cell
000287653 650_7 $$2Other$$aspatial
000287653 650_7 $$2Other$$auterus
000287653 650_7 $$2Other$$avagina
000287653 7001_ $$0P:(DE-He78)dccebbafdd9c09be357fc08c0d24629e$$aTolkachov, Alexander$$b1
000287653 7001_ $$0P:(DE-He78)1cca24518d30fa68f0b4dfba44850180$$aLammers, Fritjof$$b2$$udkfz
000287653 7001_ $$0P:(DE-He78)f6018952ec93bf5131638ee36af98dcb$$aLacour, Perrine$$b3$$udkfz
000287653 7001_ $$0P:(DE-He78)2a877d9e575a12fba128c39bc22580ec$$aDaugelaite, Klaudija$$b4$$udkfz
000287653 7001_ $$0P:(DE-He78)1088dd9d9cfbe8e797ae362bcdc691f3$$aSchneider, Nina$$b5$$udkfz
000287653 7001_ $$0P:(DE-He78)6154bf685be3d3443132aea60a61e4c3$$aKoch, Marie-Luise$$b6$$udkfz
000287653 7001_ $$0P:(DE-He78)d4405881b542f40197770d457d737895$$aPanten, Jasper$$b7$$udkfz
000287653 7001_ $$0P:(DE-He78)44a64e50f2668a630716e311870d57f2$$aGrünschläger, Florian$$b8
000287653 7001_ $$aPoth, Tanja$$b9
000287653 7001_ $$aÁvila, Bianca Machado de$$b10
000287653 7001_ $$aSchneider, Augusto$$b11
000287653 7001_ $$0P:(DE-He78)a5ec4e2fef99022a37a6b07c2fdd6325$$aHaas, Simon$$b12$$udkfz
000287653 7001_ $$0P:(DE-He78)4c21317940f3ec566480ebcdcff3e00c$$aOdom, Duncan T$$b13$$udkfz
000287653 7001_ $$0P:(DE-HGF)0$$aGonçalves, Ângela$$b14$$eLast author
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