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@ARTICLE{Winkler:287653,
      author       = {I. Winkler$^*$ and A. Tolkachov$^*$ and F. Lammers$^*$ and
                      P. Lacour$^*$ and K. Daugelaite$^*$ and N. Schneider$^*$ and
                      M.-L. Koch$^*$ and J. Panten$^*$ and F. Grünschläger$^*$
                      and T. Poth and B. M. d. Ávila and A. Schneider and S.
                      Haas$^*$ and D. T. Odom$^*$ and Â. Gonçalves$^*$},
      title        = {{T}he cycling and aging mouse female reproductive tract at
                      single-cell resolution.},
      journal      = {Cell},
      volume       = {187},
      number       = {4},
      issn         = {0092-8674},
      address      = {New York, NY},
      publisher    = {Elsevier},
      reportid     = {DKFZ-2024-00296},
      pages        = {981-998.e25},
      year         = {2024},
      note         = {DKFZ–ZMBH Alliance / 2024 Feb 15;187(4):981-998.e25 /
                      #EA:B210#LA:B210#},
      abstract     = {The female reproductive tract (FRT) undergoes extensive
                      remodeling during reproductive cycling. This recurrent
                      remodeling and how it shapes organ-specific aging remains
                      poorly explored. Using single-cell and spatial
                      transcriptomics, we systematically characterized
                      morphological and gene expression changes occurring in
                      ovary, oviduct, uterus, cervix, and vagina at each phase of
                      the mouse estrous cycle, during decidualization, and into
                      aging. These analyses reveal that fibroblasts play
                      central-and highly organ-specific-roles in FRT remodeling by
                      orchestrating extracellular matrix (ECM) reorganization and
                      inflammation. Our results suggest a model wherein recurrent
                      FRT remodeling over reproductive lifespan drives the
                      gradual, age-related development of fibrosis and chronic
                      inflammation. This hypothesis was directly tested using
                      chemical ablation of cycling, which reduced fibrotic
                      accumulation during aging. Our atlas provides extensive
                      detail into how estrus, pregnancy, and aging shape the
                      organs of the female reproductive tract and reveals the
                      unexpected cost of the recurrent remodeling required for
                      reproduction.},
      keywords     = {aging (Other) / cervix (Other) / fibrosis (Other) /
                      inflammation (Other) / ovary (Other) / oviduct (Other) /
                      single cell (Other) / spatial (Other) / uterus (Other) /
                      vagina (Other)},
      cin          = {B210 / B270 / B260 / A010 / HD01},
      ddc          = {610},
      cid          = {I:(DE-He78)B210-20160331 / I:(DE-He78)B270-20160331 /
                      I:(DE-He78)B260-20160331 / I:(DE-He78)A010-20160331 /
                      I:(DE-He78)HD01-20160331},
      pnm          = {312 - Funktionelle und strukturelle Genomforschung
                      (POF4-312)},
      pid          = {G:(DE-HGF)POF4-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:38325365},
      doi          = {10.1016/j.cell.2024.01.021},
      url          = {https://inrepo02.dkfz.de/record/287653},
}