TY  - JOUR
AU  - Klotz, Rosa
AU  - Ahmed, Azaz
AU  - Tremmel, Anja
AU  - Büsch, Christopher
AU  - Tenckhoff, Solveig
AU  - Doerr-Harim, Colette
AU  - Lock, Johan F
AU  - Brede, Elmar-Marc
AU  - Köninger, Jörg
AU  - Schiff, Jan-Henrik
AU  - Wittel, Uwe A
AU  - Hötzel, Alexander
AU  - Keck, Tobias
AU  - Nau, Carla
AU  - Amati, Anca-Laura
AU  - Koch, Christian
AU  - Diener, Markus K
AU  - Weigand, Markus A
AU  - Büchler, Markus W
AU  - Knebel, Phillip
AU  - Larmann, Jan
TI  - Thoracic Epidural Analgesia Is Not Associated With Improved Survival After Pancreatic Surgery: Long-Term Follow-Up of the Randomized Controlled PAKMAN Trial.
JO  - Anesthesia & analgesia
VL  - 140
IS  - 4
SN  - 0003-2999
CY  - [Erscheinungsort nicht ermittelbar]
PB  - Ovid
M1  - DKFZ-2024-00310
SP  - 798-810
PY  - 2025
N1  -  140(4):p 798-810, April 2025.
AB  - Perioperative thoracic epidural analgesia (EDA) and patient-controlled intravenous analgesia (PCIA) are common forms of analgesia after pancreatic surgery. Current guidelines recommend EDA over PCIA, and evidence suggests that EDA may improve long-term survival after surgery, especially in cancer patients. The aim of this study was to determine whether perioperative EDA is associated with an improved patient prognosis compared to PCIA in pancreatic surgery.The PAKMAN trial was an adaptive, pragmatic, international, multicenter, randomized controlled superiority trial conducted from June 2015 to October 2017. Three to five years after index surgery a long-term follow-up was performed from October 2020 to April 2021.For long-term follow-up of survival, 109 patients with EDA were compared to 111 patients with PCIA after partial pancreatoduodenectomy (PD). Long-term follow-up of quality of life (QoL) and pain assessment was available for 40 patients with EDA and 45 patients with PCIA (questionnaire response rate: 94
LB  - PUB:(DE-HGF)16
C6  - pmid:38335141
DO  - DOI:10.1213/ANE.0000000000006812
UR  - https://inrepo02.dkfz.de/record/287682
ER  -