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000287684 1001_ $$aLiang, Siyuan$$b0
000287684 245__ $$aTumor Neurobiology in the Pathogenesis and Therapy of Head and Neck Cancer.
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000287684 520__ $$aThe neurobiology of tumors has attracted considerable interest from clinicians and scientists and has become a multidisciplinary area of research. Neural components not only interact with tumor cells but also influence other elements within the TME, such as immune cells and vascular components, forming a polygonal relationship to synergistically facilitate tumor growth and progression. This review comprehensively summarizes the current state of the knowledge on nerve-tumor crosstalk in head and neck cancer and discusses the potential underlying mechanisms. Several mechanisms facilitating nerve-tumor crosstalk are covered, such as perineural invasion, axonogenesis, neurogenesis, neural reprogramming, and transdifferentiation, and the reciprocal interactions between the nervous and immune systems in the TME are also discussed in this review. Further understanding of the nerve-tumor crosstalk in the TME of head and neck cancer may provide new nerve-targeted treatment options and help improve clinical outcomes for patients.
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000287684 650_7 $$2Other$$ahead and neck cancer
000287684 650_7 $$2Other$$anerve–cancer crosstalk
000287684 650_7 $$2Other$$atumor neurobiology
000287684 7001_ $$0P:(DE-He78)2e5f34f1c58eda4787a14c9dc139ca5f$$aHess, Jochen$$b1$$eLast author$$udkfz
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