TY  - JOUR
AU  - Liang, Siyuan
AU  - Hess, Jochen
TI  - Tumor Neurobiology in the Pathogenesis and Therapy of Head and Neck Cancer.
JO  - Cells
VL  - 13
IS  - 3
SN  - 2073-4409
CY  - Basel
PB  - MDPI
M1  - DKFZ-2024-00312
SP  - 256
PY  - 2024
N1  - #LA:E221#
AB  - The neurobiology of tumors has attracted considerable interest from clinicians and scientists and has become a multidisciplinary area of research. Neural components not only interact with tumor cells but also influence other elements within the TME, such as immune cells and vascular components, forming a polygonal relationship to synergistically facilitate tumor growth and progression. This review comprehensively summarizes the current state of the knowledge on nerve-tumor crosstalk in head and neck cancer and discusses the potential underlying mechanisms. Several mechanisms facilitating nerve-tumor crosstalk are covered, such as perineural invasion, axonogenesis, neurogenesis, neural reprogramming, and transdifferentiation, and the reciprocal interactions between the nervous and immune systems in the TME are also discussed in this review. Further understanding of the nerve-tumor crosstalk in the TME of head and neck cancer may provide new nerve-targeted treatment options and help improve clinical outcomes for patients.
KW  - TME (Other)
KW  - head and neck cancer (Other)
KW  - nerve–cancer crosstalk (Other)
KW  - tumor neurobiology (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:38334648
C2  - pmc:PMC10854684
DO  - DOI:10.3390/cells13030256
UR  - https://inrepo02.dkfz.de/record/287684
ER  -