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@ARTICLE{Liang:287684,
      author       = {S. Liang and J. Hess$^*$},
      title        = {{T}umor {N}eurobiology in the {P}athogenesis and {T}herapy
                      of {H}ead and {N}eck {C}ancer.},
      journal      = {Cells},
      volume       = {13},
      number       = {3},
      issn         = {2073-4409},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {DKFZ-2024-00312},
      pages        = {256},
      year         = {2024},
      note         = {#LA:E221#},
      abstract     = {The neurobiology of tumors has attracted considerable
                      interest from clinicians and scientists and has become a
                      multidisciplinary area of research. Neural components not
                      only interact with tumor cells but also influence other
                      elements within the TME, such as immune cells and vascular
                      components, forming a polygonal relationship to
                      synergistically facilitate tumor growth and progression.
                      This review comprehensively summarizes the current state of
                      the knowledge on nerve-tumor crosstalk in head and neck
                      cancer and discusses the potential underlying mechanisms.
                      Several mechanisms facilitating nerve-tumor crosstalk are
                      covered, such as perineural invasion, axonogenesis,
                      neurogenesis, neural reprogramming, and
                      transdifferentiation, and the reciprocal interactions
                      between the nervous and immune systems in the TME are also
                      discussed in this review. Further understanding of the
                      nerve-tumor crosstalk in the TME of head and neck cancer may
                      provide new nerve-targeted treatment options and help
                      improve clinical outcomes for patients.},
      subtyp        = {Review Article},
      keywords     = {TME (Other) / head and neck cancer (Other) / nerve–cancer
                      crosstalk (Other) / tumor neurobiology (Other)},
      cin          = {E221},
      ddc          = {570},
      cid          = {I:(DE-He78)E221-20160331},
      pnm          = {315 - Bildgebung und Radioonkologie (POF4-315)},
      pid          = {G:(DE-HGF)POF4-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:38334648},
      pmc          = {pmc:PMC10854684},
      doi          = {10.3390/cells13030256},
      url          = {https://inrepo02.dkfz.de/record/287684},
}