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@ARTICLE{Panten:288057,
      author       = {J. Panten$^*$ and T. Heinen$^*$ and C. Ernst and N. Eling
                      and R. E. Wagner$^*$ and M. Satorius$^*$ and J. C. Marioni
                      and O. Stegle$^*$ and D. Odom$^*$},
      title        = {{T}he dynamic genetic determinants of increased
                      transcriptional divergence in spermatids.},
      journal      = {Nature Communications},
      volume       = {15},
      number       = {1},
      issn         = {2041-1723},
      address      = {[London]},
      publisher    = {Nature Publishing Group UK},
      reportid     = {DKFZ-2024-00315},
      pages        = {1272},
      year         = {2024},
      note         = {#EA:B260#EA:B270#LA:B260#LA:B270#},
      abstract     = {Cis-genetic effects are key determinants of transcriptional
                      divergence in discrete tissues and cell types. However, how
                      cis- and trans-effects act across continuous trajectories of
                      cellular differentiation in vivo is poorly understood. Here,
                      we quantify allele-specific expression during spermatogenic
                      differentiation at single-cell resolution in an F1 hybrid
                      mouse system, allowing for the comprehensive
                      characterisation of cis- and trans-genetic effects,
                      including their dynamics across cellular differentiation.
                      Collectively, almost half of the genes subject to genetic
                      regulation show evidence for dynamic cis-effects that vary
                      during differentiation. Our system also allows us to
                      robustly identify dynamic trans-effects, which are less
                      pervasive than cis-effects. In aggregate, genetic effects
                      were strongest in round spermatids, which parallels their
                      increased transcriptional divergence we identified between
                      species. Our approach provides a comprehensive
                      quantification of the variability of genetic effects in
                      vivo, and demonstrates a widely applicable strategy to
                      dissect the impact of regulatory variants on gene regulation
                      in dynamic systems.},
      cin          = {B270 / B260 / A350},
      ddc          = {500},
      cid          = {I:(DE-He78)B270-20160331 / I:(DE-He78)B260-20160331 /
                      I:(DE-He78)A350-20160331},
      pnm          = {312 - Funktionelle und strukturelle Genomforschung
                      (POF4-312)},
      pid          = {G:(DE-HGF)POF4-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:38341412},
      pmc          = {pmc:PMC10858866},
      doi          = {10.1038/s41467-024-45133-1},
      url          = {https://inrepo02.dkfz.de/record/288057},
}