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100 1 _ |a Panten, Jasper
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245 _ _ |a The dynamic genetic determinants of increased transcriptional divergence in spermatids.
260 _ _ |a [London]
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520 _ _ |a Cis-genetic effects are key determinants of transcriptional divergence in discrete tissues and cell types. However, how cis- and trans-effects act across continuous trajectories of cellular differentiation in vivo is poorly understood. Here, we quantify allele-specific expression during spermatogenic differentiation at single-cell resolution in an F1 hybrid mouse system, allowing for the comprehensive characterisation of cis- and trans-genetic effects, including their dynamics across cellular differentiation. Collectively, almost half of the genes subject to genetic regulation show evidence for dynamic cis-effects that vary during differentiation. Our system also allows us to robustly identify dynamic trans-effects, which are less pervasive than cis-effects. In aggregate, genetic effects were strongest in round spermatids, which parallels their increased transcriptional divergence we identified between species. Our approach provides a comprehensive quantification of the variability of genetic effects in vivo, and demonstrates a widely applicable strategy to dissect the impact of regulatory variants on gene regulation in dynamic systems.
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700 1 _ |a Heinen, Tobias
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700 1 _ |a Ernst, Christina
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700 1 _ |a Eling, Nils
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700 1 _ |a Wagner, Rebecca E
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700 1 _ |a Satorius, Maja
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700 1 _ |a Marioni, John C
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700 1 _ |a Stegle, Oliver
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700 1 _ |a Odom, Duncan
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773 _ _ |a 10.1038/s41467-024-45133-1
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856 4 _ |u https://inrepo02.dkfz.de/record/288057/files/s41467-024-45133-1.pdf
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