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000288060 245__ $$aDropout from exercise trials among cancer survivors-An individual patient data meta-analysis from the POLARIS study.
000288060 260__ $$aOxford [u.a.]$$bWiley-Blackwell$$c2024
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000288060 520__ $$aThe number of randomized controlled trials (RCTs) investigating the effects of exercise among cancer survivors has increased in recent years; however, participants dropping out of the trials are rarely described. The objective of the present study was to assess which combinations of participant and exercise program characteristics were associated with dropout from the exercise arms of RCTs among cancer survivors.This study used data collected in the Predicting OptimaL cAncer RehabIlitation and Supportive care (POLARIS) study, an international database of RCTs investigating the effects of exercise among cancer survivors. Thirty-four exercise trials, with a total of 2467 patients without metastatic disease randomized to an exercise arm were included. Harmonized studies included a pre and a posttest, and participants were classified as dropouts when missing all assessments at the post-intervention test. Subgroups were identified with a conditional inference tree.Overall, 9.6% of the participants dropped out. Five subgroups were identified in the conditional inference tree based on four significant associations with dropout. Most dropout was observed for participants with BMI >28.4 kg/m2 , performing supervised resistance or unsupervised mixed exercise (19.8% dropout) or had low-medium education and performed aerobic or supervised mixed exercise (13.5%). The lowest dropout was found for participants with BMI >28.4 kg/m2 and high education performing aerobic or supervised mixed exercise (5.1%), and participants with BMI ≤28.4 kg/m2 exercising during (5.2%) or post (9.5%) treatment.There are several systematic differences between cancer survivors completing and dropping out from exercise trials, possibly affecting the external validity of exercise effects.
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000288060 650_7 $$2Other$$acancer
000288060 650_7 $$2Other$$adecision tree
000288060 650_7 $$2Other$$aexercise oncology
000288060 650_7 $$2Other$$aindividual patient data meta-analysis
000288060 7001_ $$aIvarsson, Andreas$$b1
000288060 7001_ $$aVistad, Ingvild$$b2
000288060 7001_ $$00000-0002-2068-4708$$aDemmelmaier, Ingrid$$b3
000288060 7001_ $$aAaronson, Neil K$$b4
000288060 7001_ $$aRadcliffe, Gillian$$b5
000288060 7001_ $$avan Beurden, Marc$$b6
000288060 7001_ $$aBohus, Martin$$b7
000288060 7001_ $$aCourneya, Kerry S$$b8
000288060 7001_ $$aDaley, Amanda J$$b9
000288060 7001_ $$aGalvão, Daniel A$$b10
000288060 7001_ $$aGarrod, Rachel$$b11
000288060 7001_ $$aGoedendorp, Martine M$$b12
000288060 7001_ $$aGriffith, Kathleen A$$b13
000288060 7001_ $$avan Harten, Wim H$$b14
000288060 7001_ $$aHayes, Sandi C$$b15
000288060 7001_ $$aHerrero-Roman, Fernando$$b16
000288060 7001_ $$aHiensch, Anouk E$$b17
000288060 7001_ $$aIrwin, Melinda L$$b18
000288060 7001_ $$aJames, Erica$$b19
000288060 7001_ $$aKenkhuis, Marlou-Floor$$b20
000288060 7001_ $$aKersten, Marie José$$b21
000288060 7001_ $$aKnoop, Hans$$b22
000288060 7001_ $$aLucia, Alejandro$$b23
000288060 7001_ $$aMay, Anne M$$b24
000288060 7001_ $$aMcConnachie, Alex$$b25
000288060 7001_ $$avan Mechelen, Willem$$b26
000288060 7001_ $$aMutrie, Nanette$$b27
000288060 7001_ $$aNewton, Robert U$$b28
000288060 7001_ $$aNollet, Frans$$b29
000288060 7001_ $$aOldenburg, Hester S$$b30
000288060 7001_ $$aPlotnikoff, Ron$$b31
000288060 7001_ $$0P:(DE-He78)2def8f8594c8f797f5ed4398258c6cac$$aSchmidt, Martina E$$b32$$udkfz
000288060 7001_ $$aSchmitz, Katie H$$b33
000288060 7001_ $$aSchulz, Karl-Heinz$$b34
000288060 7001_ $$aShort, Camille E$$b35
000288060 7001_ $$aSonke, Gabe S$$b36
000288060 7001_ $$0P:(DE-He78)a0c2037d9054be26907a05ae520d5756$$aSteindorf, Karen$$b37$$udkfz
000288060 7001_ $$aStuiver, Martijn M$$b38
000288060 7001_ $$aTaaffe, Dennis R$$b39
000288060 7001_ $$aThorsen, Lene$$b40
000288060 7001_ $$aVelthuis, Miranda J$$b41
000288060 7001_ $$aWenzel, Jennifer$$b42
000288060 7001_ $$aWinters-Stone, Kerri M$$b43
000288060 7001_ $$0P:(DE-He78)60b584aeef81e4c57fd111fa63779b73$$aWiskemann, Joachim$$b44$$udkfz
000288060 7001_ $$aBerntsen, Sveinung$$b45
000288060 7001_ $$00000-0002-8095-436X$$aBuffart, Laurien M$$b46
000288060 773__ $$0PERI:(DE-600)2025503-2$$a10.1111/sms.14575$$gVol. 34, no. 2, p. e14575$$n2$$pe14575$$tScandinavian journal of medicine & science in sports$$v34$$x0905-7188$$y2024
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