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000288061 1001_ $$00000-0002-0447-759X$$aLamanna, Francesco$$b0
000288061 245__ $$aA lamprey neural cell type atlas illuminates the origins of the vertebrate brain.
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000288061 520__ $$aThe vertebrate brain emerged more than ~500 million years ago in common evolutionary ancestors. To systematically trace its cellular and molecular origins, we established a spatially resolved cell type atlas of the entire brain of the sea lamprey-a jawless species whose phylogenetic position affords the reconstruction of ancestral vertebrate traits-based on extensive single-cell RNA-seq and in situ sequencing data. Comparisons of this atlas to neural data from the mouse and other jawed vertebrates unveiled various shared features that enabled the reconstruction of cell types, tissue structures and gene expression programs of the ancestral vertebrate brain. However, our analyses also revealed key tissues and cell types that arose later in evolution. For example, the ancestral brain was probably devoid of cerebellar cell types and oligodendrocytes (myelinating cells); our data suggest that the latter emerged from astrocyte-like evolutionary precursors in the jawed vertebrate lineage. Altogether, our work illuminates the cellular and molecular architecture of the ancestral vertebrate brain and provides a foundation for exploring its diversification during evolution.
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000288061 7001_ $$00009-0007-0965-2493$$aHervas-Sotomayor, Francisca$$b1
000288061 7001_ $$aOel, A Phillip$$b2
000288061 7001_ $$00000-0002-4239-0014$$aJandzik, David$$b3
000288061 7001_ $$00000-0001-8239-2965$$aSobrido-Cameán, Daniel$$b4
000288061 7001_ $$aSantos-Durán, Gabriel N$$b5
000288061 7001_ $$00000-0003-1186-4085$$aMartik, Megan L$$b6
000288061 7001_ $$00000-0002-3740-3378$$aStundl, Jan$$b7
000288061 7001_ $$aGreen, Stephen A$$b8
000288061 7001_ $$aBrüning, Thoomke$$b9
000288061 7001_ $$aMößinger, Katharina$$b10
000288061 7001_ $$0P:(DE-He78)4556f6197ebc4a0679f8cf26a6d9c119$$aSchmidt, Julia$$b11$$udkfz
000288061 7001_ $$aSchneider, Celine$$b12
000288061 7001_ $$00000-0003-1733-8385$$aSepp, Mari$$b13
000288061 7001_ $$00000-0003-2116-2511$$aMurat, Florent$$b14
000288061 7001_ $$00000-0001-5333-5531$$aSmith, Jeramiah J$$b15
000288061 7001_ $$aBronner, Marianne E$$b16
000288061 7001_ $$aRodicio, María Celina$$b17
000288061 7001_ $$00000-0002-7507-080X$$aBarreiro-Iglesias, Antón$$b18
000288061 7001_ $$00000-0002-8182-6028$$aMedeiros, Daniel M$$b19
000288061 7001_ $$00000-0001-7833-050X$$aArendt, Detlev$$b20
000288061 7001_ $$00000-0001-7563-839X$$aKaessmann, Henrik$$b21
000288061 773__ $$0PERI:(DE-600)2879715-2$$a10.1038/s41559-023-02170-1$$gVol. 7, no. 10, p. 1714 - 1728$$n10$$p1714 - 1728$$tNature ecology & evolution$$v7$$x2397-334X$$y2023
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