TY  - JOUR
AU  - Lamanna, Francesco
AU  - Hervas-Sotomayor, Francisca
AU  - Oel, A Phillip
AU  - Jandzik, David
AU  - Sobrido-Cameán, Daniel
AU  - Santos-Durán, Gabriel N
AU  - Martik, Megan L
AU  - Stundl, Jan
AU  - Green, Stephen A
AU  - Brüning, Thoomke
AU  - Mößinger, Katharina
AU  - Schmidt, Julia
AU  - Schneider, Celine
AU  - Sepp, Mari
AU  - Murat, Florent
AU  - Smith, Jeramiah J
AU  - Bronner, Marianne E
AU  - Rodicio, María Celina
AU  - Barreiro-Iglesias, Antón
AU  - Medeiros, Daniel M
AU  - Arendt, Detlev
AU  - Kaessmann, Henrik
TI  - A lamprey neural cell type atlas illuminates the origins of the vertebrate brain.
JO  - Nature ecology & evolution
VL  - 7
IS  - 10
SN  - 2397-334X
CY  - London
PB  - Nature Publishing Group
M1  - DKFZ-2024-00319
SP  - 1714 - 1728
PY  - 2023
N1  - DKFZ-ZMBH Alliance
AB  - The vertebrate brain emerged more than  500 million years ago in common evolutionary ancestors. To systematically trace its cellular and molecular origins, we established a spatially resolved cell type atlas of the entire brain of the sea lamprey-a jawless species whose phylogenetic position affords the reconstruction of ancestral vertebrate traits-based on extensive single-cell RNA-seq and in situ sequencing data. Comparisons of this atlas to neural data from the mouse and other jawed vertebrates unveiled various shared features that enabled the reconstruction of cell types, tissue structures and gene expression programs of the ancestral vertebrate brain. However, our analyses also revealed key tissues and cell types that arose later in evolution. For example, the ancestral brain was probably devoid of cerebellar cell types and oligodendrocytes (myelinating cells); our data suggest that the latter emerged from astrocyte-like evolutionary precursors in the jawed vertebrate lineage. Altogether, our work illuminates the cellular and molecular architecture of the ancestral vertebrate brain and provides a foundation for exploring its diversification during evolution.
LB  - PUB:(DE-HGF)16
C6  - pmid:37710042
C2  - pmc:PMC10555824
DO  - DOI:10.1038/s41559-023-02170-1
UR  - https://inrepo02.dkfz.de/record/288061
ER  -