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@ARTICLE{Pachowsky:288085,
      author       = {M. L. Pachowsky and S. Söllner and K. Gelse and J. Sambale
                      and A. M. Nagel$^*$ and G. Schett and M. Saake and M. Uder
                      and F. W. Roemer and R. Heiss},
      title        = {{P}rimary anterior cruciate ligament repair-morphological
                      and quantitative assessment by 7-{T} {MRI} and clinical
                      outcome after 1.5 years.},
      journal      = {European radiology},
      volume       = {34},
      number       = {8},
      issn         = {0938-7994},
      address      = {Heidelberg},
      publisher    = {Springer},
      reportid     = {DKFZ-2024-00339},
      pages        = {5007-5015},
      year         = {2024},
      note         = {2024 Aug;34(8):5007-5015},
      abstract     = {The purpose of this study was to assess morphological and
                      quantitative changes of the anterior cruciate ligament (ACL)
                      and cartilage after ACL repair.7T MRI of the knee was
                      acquired in 31 patients 1.5 years after ACL repair and in 13
                      controls. Proton density-weighted images with fat saturation
                      (PD-fs) were acquired to assess ACL width, signal intensity,
                      elongation, and fraying. T2/T2* mapping was performed for
                      assessment of ACL and cartilage. Segmentation of the ACL,
                      femoral, and tibial cartilage was carried out at 12 ROIs.
                      The outcome evaluation consisted of the Lysholm Knee Score
                      and International Knee Documentation Committee (IKDC)
                      subjective score and clinical examination.ACL showed a
                      normal signal intensity in $96.8\%$ and an increased width
                      in $76.5\%$ after repair. Fraying occurred in $22.6\%$
                      without having an impact on the clinical outcome (Lysholm
                      score: 90.39 ± 9.75, p = 0.76 compared to controls). T2
                      analysis of the ACL revealed no difference between patients
                      and controls (p = 0.74). Compared to controls, assessment of
                      the femoral and tibial cartilage showed a significant
                      increase of T2* times in all ROIs, except at the
                      posterolateral femur. Patients presented a good outcome in
                      clinical examination with a Lysholm score of 87.19 ± 14.89
                      and IKDC of 80.23 ± 16.84.T2 mapping results suggest that
                      the tissue composition of the ACL after repair is similar to
                      that of a native ACL after surgery, whereas the ACL exhibits
                      an increased width. Fraying of the ACL can occur without
                      having any impact on functional outcomes. T2* analysis
                      revealed early degradation at the cartilage.MRI represents a
                      noninvasive diagnostic tool for the morphological and
                      compositional assessment of the anterior cruciate ligament
                      after repair, whereas knowledge about post-surgical
                      alterations is crucial for adequate imaging
                      interpretation.• There has been renewed interest in
                      repairing the anterior cruciate ligament with a proximally
                      torn ligament. • T2 times of the anterior cruciate
                      ligament do not differ between anterior cruciate ligament
                      repair patients and controls. • T2 mapping may serve as a
                      surrogate for the evaluation of the anterior cruciate
                      ligament after repair.},
      keywords     = {Cartilage (Other) / Knee (Other) / Ligaments (Other) /
                      Magnetic resonance imaging (Other) / Orthopedics (Other)},
      cin          = {E020},
      ddc          = {610},
      cid          = {I:(DE-He78)E020-20160331},
      pnm          = {315 - Bildgebung und Radioonkologie (POF4-315)},
      pid          = {G:(DE-HGF)POF4-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:38345606},
      doi          = {10.1007/s00330-024-10603-z},
      url          = {https://inrepo02.dkfz.de/record/288085},
}