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000288088 1001_ $$aPapadimitriou, Nikos$$b0
000288088 245__ $$aBody size and risk of colorectal cancer molecular defined subtypes and pathways: Mendelian randomization analyses.
000288088 260__ $$aAmsterdam [u.a.]$$bElsevier$$c2024
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000288088 520__ $$aObesity has been positively associated with most molecular subtypes of colorectal cancer (CRC); however, the magnitude and the causality of these associations is uncertain.We used Mendelian randomization (MR) to examine potential causal relationships between body size traits (body mass index [BMI], waist circumference, and body fat percentage) with risks of Jass classification types and individual subtypes of CRC (microsatellite instability [MSI] status, CpG island methylator phenotype [CIMP] status, BRAF and KRAS mutations). Summary data on tumour markers were obtained from two genetic consortia (CCFR, GECCO).A 1-standard deviation (SD:5.1 kg/m2) increment in BMI levels was found to increase risks of Jass type 1MSI-high,CIMP-high,BRAF-mutated,KRAS-wildtype (odds ratio [OR]: 2.14, 95% confidence interval [CI]: 1.46, 3.13; p-value = 9 × 10-5) and Jass type 2non-MSI-high,CIMP-high,BRAF-mutated,KRAS-wildtype CRC (OR: 2.20, 95% CI: 1.26, 3.86; p-value = 0.005). The magnitude of these associations was stronger compared with Jass type 4non-MSI-high,CIMP-low/negative,BRAF-wildtype,KRAS-wildtype CRC (p-differences: 0.03 and 0.04, respectively). A 1-SD (SD:13.4 cm) increment in waist circumference increased risk of Jass type 3non-MSI-high,CIMP-low/negative,BRAF-wildtype,KRAS-mutated (OR 1.73, 95% CI: 1.34, 2.25; p-value = 9 × 10-5) that was stronger compared with Jass type 4 CRC (p-difference: 0.03). A higher body fat percentage (SD:8.5%) increased risk of Jass type 1 CRC (OR: 2.59, 95% CI: 1.49, 4.48; p-value = 0.001), which was greater than Jass type 4 CRC (p-difference: 0.03).Body size was more strongly linked to the serrated (Jass types 1 and 2) and alternate (Jass type 3) pathways of colorectal carcinogenesis in comparison to the traditional pathway (Jass type 4).Cancer Research UK, National Institute for Health Research, Medical Research Council, National Institutes of Health, National Cancer Institute, American Institute for Cancer Research, Brigham and Women's Hospital, Prevent Cancer Foundation, Victorian Cancer Agency, Swedish Research Council, Swedish Cancer Society, Region Västerbotten, Knut and Alice Wallenberg Foundation, Lion's Cancer Research Foundation, Insamlingsstiftelsen, Umeå University. Full funding details are provided in acknowledgements.
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000288088 650_7 $$2Other$$aColorectal cancer
000288088 650_7 $$2Other$$aMendelian randomization
000288088 650_7 $$2Other$$aMolecular subtypes
000288088 650_7 $$2Other$$aObesity
000288088 7001_ $$aQu, Conghui$$b1
000288088 7001_ $$aHarrison, Tabitha A$$b2
000288088 7001_ $$aBever, Alaina M$$b3
000288088 7001_ $$aMartin, Richard M$$b4
000288088 7001_ $$aTsilidis, Konstantinos K$$b5
000288088 7001_ $$aNewcomb, Polly A$$b6
000288088 7001_ $$aThibodeau, Stephen N$$b7
000288088 7001_ $$aNewton, Christina C$$b8
000288088 7001_ $$aUm, Caroline Y$$b9
000288088 7001_ $$aObón-Santacana, Mireia$$b10
000288088 7001_ $$aMoreno, Victor$$b11
000288088 7001_ $$0P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2$$aBrenner, Hermann$$b12$$udkfz
000288088 7001_ $$0P:(DE-He78)6c325c717056d7ccd38066629f7dff6b$$aMandic, Marko$$b13$$udkfz
000288088 7001_ $$0P:(DE-He78)c259d6cc99edf5c7bc7ce22c7f87c253$$aChang-Claude, Jenny$$b14$$udkfz
000288088 7001_ $$0P:(DE-He78)6c5d058b7552d071a7fa4c5e943fff0f$$aHoffmeister, Michael$$b15$$udkfz
000288088 7001_ $$aPellatt, Andrew J$$b16
000288088 7001_ $$aSchoen, Robert E$$b17
000288088 7001_ $$aHarlid, Sophia$$b18
000288088 7001_ $$aOgino, Shuji$$b19
000288088 7001_ $$aUgai, Tomotaka$$b20
000288088 7001_ $$aBuchanan, Daniel D$$b21
000288088 7001_ $$aLynch, Brigid M$$b22
000288088 7001_ $$aGruber, Stephen B$$b23
000288088 7001_ $$aCao, Yin$$b24
000288088 7001_ $$aHsu, Li$$b25
000288088 7001_ $$aHuyghe, Jeroen R$$b26
000288088 7001_ $$aLin, Yi$$b27
000288088 7001_ $$aSteinfelder, Robert S$$b28
000288088 7001_ $$aSun, Wei$$b29
000288088 7001_ $$aVan Guelpen, Bethany$$b30
000288088 7001_ $$aZaidi, Syed H$$b31
000288088 7001_ $$aToland, Amanda E$$b32
000288088 7001_ $$aBerndt, Sonja I$$b33
000288088 7001_ $$aHuang, Wen-Yi$$b34
000288088 7001_ $$aAglago, Elom K$$b35
000288088 7001_ $$aDrew, David A$$b36
000288088 7001_ $$aFrench, Amy J$$b37
000288088 7001_ $$aGeorgeson, Peter$$b38
000288088 7001_ $$aGiannakis, Marios$$b39
000288088 7001_ $$aHullar, Meredith$$b40
000288088 7001_ $$aNowak, Johnathan A$$b41
000288088 7001_ $$aThomas, Claire E$$b42
000288088 7001_ $$aLe Marchand, Loic$$b43
000288088 7001_ $$aCheng, Iona$$b44
000288088 7001_ $$aGallinger, Steven$$b45
000288088 7001_ $$aJenkins, Mark A$$b46
000288088 7001_ $$aGunter, Marc J$$b47
000288088 7001_ $$aCampbell, Peter T$$b48
000288088 7001_ $$aPeters, Ulrike$$b49
000288088 7001_ $$aSong, Mingyang$$b50
000288088 7001_ $$aPhipps, Amanda I$$b51
000288088 7001_ $$aMurphy, Neil$$b52
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