TY  - JOUR
AU  - Papadimitriou, Nikos
AU  - Qu, Conghui
AU  - Harrison, Tabitha A
AU  - Bever, Alaina M
AU  - Martin, Richard M
AU  - Tsilidis, Konstantinos K
AU  - Newcomb, Polly A
AU  - Thibodeau, Stephen N
AU  - Newton, Christina C
AU  - Um, Caroline Y
AU  - Obón-Santacana, Mireia
AU  - Moreno, Victor
AU  - Brenner, Hermann
AU  - Mandic, Marko
AU  - Chang-Claude, Jenny
AU  - Hoffmeister, Michael
AU  - Pellatt, Andrew J
AU  - Schoen, Robert E
AU  - Harlid, Sophia
AU  - Ogino, Shuji
AU  - Ugai, Tomotaka
AU  - Buchanan, Daniel D
AU  - Lynch, Brigid M
AU  - Gruber, Stephen B
AU  - Cao, Yin
AU  - Hsu, Li
AU  - Huyghe, Jeroen R
AU  - Lin, Yi
AU  - Steinfelder, Robert S
AU  - Sun, Wei
AU  - Van Guelpen, Bethany
AU  - Zaidi, Syed H
AU  - Toland, Amanda E
AU  - Berndt, Sonja I
AU  - Huang, Wen-Yi
AU  - Aglago, Elom K
AU  - Drew, David A
AU  - French, Amy J
AU  - Georgeson, Peter
AU  - Giannakis, Marios
AU  - Hullar, Meredith
AU  - Nowak, Johnathan A
AU  - Thomas, Claire E
AU  - Le Marchand, Loic
AU  - Cheng, Iona
AU  - Gallinger, Steven
AU  - Jenkins, Mark A
AU  - Gunter, Marc J
AU  - Campbell, Peter T
AU  - Peters, Ulrike
AU  - Song, Mingyang
AU  - Phipps, Amanda I
AU  - Murphy, Neil
TI  - Body size and risk of colorectal cancer molecular defined subtypes and pathways: Mendelian randomization analyses.
JO  - EBioMedicine
VL  - 101
SN  - 2352-3964
CY  - Amsterdam [u.a.]
PB  - Elsevier
M1  - DKFZ-2024-00342
SP  - 105010
PY  - 2024
AB  - Obesity has been positively associated with most molecular subtypes of colorectal cancer (CRC); however, the magnitude and the causality of these associations is uncertain.We used Mendelian randomization (MR) to examine potential causal relationships between body size traits (body mass index [BMI], waist circumference, and body fat percentage) with risks of Jass classification types and individual subtypes of CRC (microsatellite instability [MSI] status, CpG island methylator phenotype [CIMP] status, BRAF and KRAS mutations). Summary data on tumour markers were obtained from two genetic consortia (CCFR, GECCO).A 1-standard deviation (SD:5.1 kg/m2) increment in BMI levels was found to increase risks of Jass type 1MSI-high,CIMP-high,BRAF-mutated,KRAS-wildtype (odds ratio [OR]: 2.14, 95
KW  - Colorectal cancer (Other)
KW  - Mendelian randomization (Other)
KW  - Molecular subtypes (Other)
KW  - Obesity (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:38350331
DO  - DOI:10.1016/j.ebiom.2024.105010
UR  - https://inrepo02.dkfz.de/record/288088
ER  -