TY  - JOUR
AU  - Schreck, Nicholas
AU  - Slynko, Alla
AU  - Saadati, Maral
AU  - Benner, Axel
TI  - Statistical plasmode simulations-Potentials, challenges and recommendations.
JO  - Statistics in medicine
VL  - 43
IS  - 9
SN  - 0277-6715
CY  - Chichester [u.a.]
PB  - Wiley
M1  - DKFZ-2024-00353
SP  - 1804-1825
PY  - 2024
N1  - TUTORIAL IN BIOSTATISTICS /  #EA:C060#LA:C060# / 2024 Apr 30;43(9):1804-1825
AB  - Statistical data simulation is essential in the development of statistical models and methods as well as in their performance evaluation. To capture complex data structures, in particular for high-dimensional data, a variety of simulation approaches have been introduced including parametric and the so-called plasmode simulations. While there are concerns about the realism of parametrically simulated data, it is widely claimed that plasmodes come very close to reality with some aspects of the 'truth' known. However, there are no explicit guidelines or state-of-the-art on how to perform plasmode data simulations. In the present paper, we first review existing literature and introduce the concept of statistical plasmode simulation. We then discuss advantages and challenges of statistical plasmodes and provide a step-wise procedure for their generation, including key steps to their implementation and reporting. Finally, we illustrate the concept of statistical plasmodes as well as the proposed plasmode generation procedure by means of a public real RNA data set on breast carcinoma patients.
KW  - data-generating process (Other)
KW  - outcome-generating model (Other)
KW  - parametric simulations (Other)
KW  - resampling (Other)
KW  - statistical plasmodes (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:38356231
DO  - DOI:10.1002/sim.10012
UR  - https://inrepo02.dkfz.de/record/288132
ER  -