%0 Journal Article
%A Rinaldi, Sabina
%A Dossus, Laure
%A Keski-Rahkonen, Pekka
%A Kiss, Agneta
%A Navionis, Anne-Sophie
%A Biessy, Carine
%A Travis, Ruth
%A Weiderpass, Elisabete
%A Romieu, Isabelle
%A Eriksen, Anne Kirstine
%A Tjonneland, Anne
%A Kvaskoff, Marina
%A Canonico, Marianne
%A Truong, Thérèse
%A Katzke, Verena
%A Kaaks, Rudolf
%A Catalano, Alberto
%A Panico, Salvatore
%A Masala, Giovanna
%A Tumino, Rosario
%A Lukic, Marko
%A Olsen, Karina Standahl
%A Zamora-Ros, Raul
%A Santiuste, Carmen
%A Aizpurua Atxega, Amaia
%A Guevara, Marcela
%A Rodriguez-Barranco, Miguel
%A Sandstrom, Maria
%A Hennings, Joakim
%A Almquist, Martin
%A Aglago Kouassivi, Elom
%A Christakoudi, Sofia
%A Gunter, Marc
%A Franceschi, Silvia
%T Circulating endogenous sex steroids and risk of differentiated thyroid carcinoma in men and women.
%J International journal of cancer
%V 154
%N 12
%@ 0020-7136
%C Bognor Regis
%I Wiley-Liss
%M DKFZ-2024-00363
%P 2064-2074
%D 2024
%Z 2024 Jun 15;154(12):2064-2074
%X Thyroid cancer (TC) is substantially more common in women than in men, pointing to a possible role of sex steroid hormones. We investigated the association between circulating sex steroid hormones, sex hormone binding globulin (SHBG) and the risk of differentiated TC in men and women within the European Prospective Investigation into Cancer and nutrition (EPIC) cohort. During follow-up, we identified 333 first primary incident cases of differentiated TC (152 in pre/peri-menopausal women, 111 in post-menopausal women, and 70 in men) and 706 cancer-free controls. Women taking exogenous hormones at blood donation were excluded. Plasma concentrations of testosterone, androstenedione, dehydroepiandrosterone, estradiol, estrone and progesterone (in pre-menopausal women only) were performed using liquid chromatography/mass spectrometry method. SHBG concentrations were measured by immunoassay. Odds ratios (ORs) were estimated using conditional logistic regression models adjusted for possible confounders. No significant associations were observed in men and postmenopausal women, while a borderline significant increase in differentiated TC risk was observed with increasing testosterone (adjusted OR T3 vs T1: 1.68, 95
%K differentiated thyroid cancer (Other)
%K prospective study (Other)
%K sex steroids (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:38357914
%R 10.1002/ijc.34872
%U https://inrepo02.dkfz.de/record/288149