TY  - JOUR
AU  - Rinaldi, Sabina
AU  - Dossus, Laure
AU  - Keski-Rahkonen, Pekka
AU  - Kiss, Agneta
AU  - Navionis, Anne-Sophie
AU  - Biessy, Carine
AU  - Travis, Ruth
AU  - Weiderpass, Elisabete
AU  - Romieu, Isabelle
AU  - Eriksen, Anne Kirstine
AU  - Tjonneland, Anne
AU  - Kvaskoff, Marina
AU  - Canonico, Marianne
AU  - Truong, Thérèse
AU  - Katzke, Verena
AU  - Kaaks, Rudolf
AU  - Catalano, Alberto
AU  - Panico, Salvatore
AU  - Masala, Giovanna
AU  - Tumino, Rosario
AU  - Lukic, Marko
AU  - Olsen, Karina Standahl
AU  - Zamora-Ros, Raul
AU  - Santiuste, Carmen
AU  - Aizpurua Atxega, Amaia
AU  - Guevara, Marcela
AU  - Rodriguez-Barranco, Miguel
AU  - Sandstrom, Maria
AU  - Hennings, Joakim
AU  - Almquist, Martin
AU  - Aglago Kouassivi, Elom
AU  - Christakoudi, Sofia
AU  - Gunter, Marc
AU  - Franceschi, Silvia
TI  - Circulating endogenous sex steroids and risk of differentiated thyroid carcinoma in men and women.
JO  - International journal of cancer
VL  - 154
IS  - 12
SN  - 0020-7136
CY  - Bognor Regis
PB  - Wiley-Liss
M1  - DKFZ-2024-00363
SP  - 2064-2074
PY  - 2024
N1  - 2024 Jun 15;154(12):2064-2074
AB  - Thyroid cancer (TC) is substantially more common in women than in men, pointing to a possible role of sex steroid hormones. We investigated the association between circulating sex steroid hormones, sex hormone binding globulin (SHBG) and the risk of differentiated TC in men and women within the European Prospective Investigation into Cancer and nutrition (EPIC) cohort. During follow-up, we identified 333 first primary incident cases of differentiated TC (152 in pre/peri-menopausal women, 111 in post-menopausal women, and 70 in men) and 706 cancer-free controls. Women taking exogenous hormones at blood donation were excluded. Plasma concentrations of testosterone, androstenedione, dehydroepiandrosterone, estradiol, estrone and progesterone (in pre-menopausal women only) were performed using liquid chromatography/mass spectrometry method. SHBG concentrations were measured by immunoassay. Odds ratios (ORs) were estimated using conditional logistic regression models adjusted for possible confounders. No significant associations were observed in men and postmenopausal women, while a borderline significant increase in differentiated TC risk was observed with increasing testosterone (adjusted OR T3 vs T1: 1.68, 95
KW  - differentiated thyroid cancer (Other)
KW  - prospective study (Other)
KW  - sex steroids (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:38357914
DO  - DOI:10.1002/ijc.34872
UR  - https://inrepo02.dkfz.de/record/288149
ER  -