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@ARTICLE{Rinaldi:288149,
      author       = {S. Rinaldi and L. Dossus and P. Keski-Rahkonen and A. Kiss
                      and A.-S. Navionis and C. Biessy and R. Travis and E.
                      Weiderpass and I. Romieu and A. K. Eriksen and A. Tjonneland
                      and M. Kvaskoff and M. Canonico and T. Truong and V.
                      Katzke$^*$ and R. Kaaks$^*$ and A. Catalano and S. Panico
                      and G. Masala and R. Tumino and M. Lukic and K. S. Olsen and
                      R. Zamora-Ros and C. Santiuste and A. Aizpurua Atxega and M.
                      Guevara and M. Rodriguez-Barranco and M. Sandstrom and J.
                      Hennings and M. Almquist and E. Aglago Kouassivi and S.
                      Christakoudi and M. Gunter and S. Franceschi},
      title        = {{C}irculating endogenous sex steroids and risk of
                      differentiated thyroid carcinoma in men and women.},
      journal      = {International journal of cancer},
      volume       = {154},
      number       = {12},
      issn         = {0020-7136},
      address      = {Bognor Regis},
      publisher    = {Wiley-Liss},
      reportid     = {DKFZ-2024-00363},
      pages        = {2064-2074},
      year         = {2024},
      note         = {2024 Jun 15;154(12):2064-2074},
      abstract     = {Thyroid cancer (TC) is substantially more common in women
                      than in men, pointing to a possible role of sex steroid
                      hormones. We investigated the association between
                      circulating sex steroid hormones, sex hormone binding
                      globulin (SHBG) and the risk of differentiated TC in men and
                      women within the European Prospective Investigation into
                      Cancer and nutrition (EPIC) cohort. During follow-up, we
                      identified 333 first primary incident cases of
                      differentiated TC (152 in pre/peri-menopausal women, 111 in
                      post-menopausal women, and 70 in men) and 706 cancer-free
                      controls. Women taking exogenous hormones at blood donation
                      were excluded. Plasma concentrations of testosterone,
                      androstenedione, dehydroepiandrosterone, estradiol, estrone
                      and progesterone (in pre-menopausal women only) were
                      performed using liquid chromatography/mass spectrometry
                      method. SHBG concentrations were measured by immunoassay.
                      Odds ratios (ORs) were estimated using conditional logistic
                      regression models adjusted for possible confounders. No
                      significant associations were observed in men and
                      postmenopausal women, while a borderline significant
                      increase in differentiated TC risk was observed with
                      increasing testosterone (adjusted OR T3 vs T1: 1.68, $95\%$
                      CI: 0.96-2.92, ptrend = .06) and androstenedione
                      concentrations in pre/perimenopausal women (adjusted OR T3
                      vs T1: 1.78, $95\%$ CI: 0.96-3.30, ptrend = .06,
                      respectively). A borderline decrease in risk was observed
                      for the highest progesterone/estradiol ratio (adjusted OR T3
                      vs T1: 0.54, $95\%$ CI: 0.28-1.05, ptrend = .07). Overall,
                      our results do not support a major role of circulating sex
                      steroids in the etiology of differentiated TC in
                      post-menopausal women and men but may suggest an involvement
                      of altered sex steroid production in pre-menopausal women.},
      keywords     = {differentiated thyroid cancer (Other) / prospective study
                      (Other) / sex steroids (Other)},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:38357914},
      doi          = {10.1002/ijc.34872},
      url          = {https://inrepo02.dkfz.de/record/288149},
}