TY  - JOUR
AU  - Von Holle, Ann
AU  - Adami, Hans-Olov
AU  - Baglietto, Laura
AU  - Berrington, Amy
AU  - Bertrand, Kimberly A
AU  - Blot, William
AU  - Chen, Yu
AU  - DeHart, Jessica Clague
AU  - Dossus, Laure
AU  - Eliassen, A Heather
AU  - Fournier, Agnes
AU  - Garcia-Closas, Montse
AU  - Giles, Graham
AU  - Guevara, Marcela
AU  - Hankinson, Susan E
AU  - Heath, Alicia
AU  - Jones, Michael E
AU  - Joshu, Corinne E
AU  - Kaaks, Rudolf
AU  - Kirsh, Victoria A
AU  - Kitahara, Cari M
AU  - Koh, Woon-Puay
AU  - Linet, Martha S
AU  - Park, Hannah Lui
AU  - Masala, Giovanna
AU  - Mellemkjaer, Lene
AU  - Milne, Roger L
AU  - O'Brien, Katie M
AU  - Palmer, Julie R
AU  - Riboli, Elio
AU  - Rohan, Thomas E
AU  - Shrubsole, Martha J
AU  - Sund, Malin
AU  - Tamimi, Rulla
AU  - Tin Tin, Sandar
AU  - Visvanathan, Kala
AU  - Vermeulen, Roel Ch
AU  - Weiderpass, Elisabete
AU  - Willett, Walter C
AU  - Yuan, Jian-Min
AU  - Zeleniuch-Jacquotte, Anne
AU  - Nichols, Hazel B
AU  - Sandler, Dale P
AU  - Swerdlow, Anthony J
AU  - Schoemaker, Minouk J
AU  - Weinberg, Clarice R
TI  - BMI and breast cancer risk around age at menopause.
JO  - Cancer epidemiology
VL  - 89
SN  - 1877-7821
CY  - Amsterdam [u.a.]
PB  - Elsevier
M1  - DKFZ-2024-00392
SP  - 102545
PY  - 2024
AB  - A high body mass index (BMI, kg/m2) is associated with decreased risk of breast cancer before menopause, but increased risk after menopause. Exactly when this reversal occurs in relation to menopause is unclear. Locating that change point could provide insight into the role of adiposity in breast cancer etiology.We examined the association between BMI and breast cancer risk in the Premenopausal Breast Cancer Collaborative Group, from age 45 up to breast cancer diagnosis, loss to follow-up, death, or age 55, whichever came first. Analyses included 609,880 women in 16 prospective studies, including 9956 who developed breast cancer before age 55. We fitted three BMI hazard ratio (HR) models over age-time: constant, linear, or nonlinear (via splines), applying piecewise exponential additive mixed models, with age as the primary time scale. We divided person-time into four strata: premenopause; postmenopause due to natural menopause; postmenopause because of interventional loss of ovarian function (bilateral oophorectomy (BO) or chemotherapy); postmenopause due to hysterectomy without BO. Sensitivity analyses included stratifying by BMI in young adulthood, or excluding women using menopausal hormone therapy.The constant BMI HR model provided the best fit for all four menopausal status groups. Under this model, the estimated association between a five-unit increment in BMI and breast cancer risk was HR=0.87 (95
KW  - Body mass index (Other)
KW  - Breast neoplasms (Other)
KW  - Middle aged (Other)
KW  - Postmenopause (Other)
KW  - Premenopause (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:38377945
DO  - DOI:10.1016/j.canep.2024.102545
UR  - https://inrepo02.dkfz.de/record/288522
ER  -