% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{VonHolle:288522,
      author       = {A. Von Holle and H.-O. Adami and L. Baglietto and A.
                      Berrington and K. A. Bertrand and W. Blot and Y. Chen and J.
                      C. DeHart and L. Dossus and A. H. Eliassen and A. Fournier
                      and M. Garcia-Closas and G. Giles and M. Guevara and S. E.
                      Hankinson and A. Heath and M. E. Jones and C. E. Joshu and
                      R. Kaaks$^*$ and V. A. Kirsh and C. M. Kitahara and W.-P.
                      Koh and M. S. Linet and H. L. Park and G. Masala and L.
                      Mellemkjaer and R. L. Milne and K. M. O'Brien and J. R.
                      Palmer and E. Riboli and T. E. Rohan and M. J. Shrubsole and
                      M. Sund and R. Tamimi and S. Tin Tin and K. Visvanathan and
                      R. C. Vermeulen and E. Weiderpass and W. C. Willett and
                      J.-M. Yuan and A. Zeleniuch-Jacquotte and H. B. Nichols and
                      D. P. Sandler and A. J. Swerdlow and M. J. Schoemaker and C.
                      R. Weinberg},
      title        = {{BMI} and breast cancer risk around age at menopause.},
      journal      = {Cancer epidemiology},
      volume       = {89},
      issn         = {1877-7821},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier},
      reportid     = {DKFZ-2024-00392},
      pages        = {102545},
      year         = {2024},
      abstract     = {A high body mass index (BMI, kg/m2) is associated with
                      decreased risk of breast cancer before menopause, but
                      increased risk after menopause. Exactly when this reversal
                      occurs in relation to menopause is unclear. Locating that
                      change point could provide insight into the role of
                      adiposity in breast cancer etiology.We examined the
                      association between BMI and breast cancer risk in the
                      Premenopausal Breast Cancer Collaborative Group, from age 45
                      up to breast cancer diagnosis, loss to follow-up, death, or
                      age 55, whichever came first. Analyses included 609,880
                      women in 16 prospective studies, including 9956 who
                      developed breast cancer before age 55. We fitted three BMI
                      hazard ratio (HR) models over age-time: constant, linear, or
                      nonlinear (via splines), applying piecewise exponential
                      additive mixed models, with age as the primary time scale.
                      We divided person-time into four strata: premenopause;
                      postmenopause due to natural menopause; postmenopause
                      because of interventional loss of ovarian function
                      (bilateral oophorectomy (BO) or chemotherapy); postmenopause
                      due to hysterectomy without BO. Sensitivity analyses
                      included stratifying by BMI in young adulthood, or excluding
                      women using menopausal hormone therapy.The constant BMI HR
                      model provided the best fit for all four menopausal status
                      groups. Under this model, the estimated association between
                      a five-unit increment in BMI and breast cancer risk was
                      HR=0.87 $(95\%$ CI: 0.85, 0.89) before menopause, HR=1.00
                      $(95\%$ CI: 0.96, 1.04) after natural menopause, HR=0.99
                      $(95\%$ CI: 0.93, 1.05) after interventional loss of ovarian
                      function, and HR=0.88 $(95\%$ CI: 0.76, 1.02) after
                      hysterectomy without BO.The BMI breast cancer HRs remained
                      less than or near one during the 45-55 year age range
                      indicating that the transition to a positive association
                      between BMI and risk occurs after age 55.},
      keywords     = {Body mass index (Other) / Breast neoplasms (Other) / Middle
                      aged (Other) / Postmenopause (Other) / Premenopause (Other)},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:38377945},
      doi          = {10.1016/j.canep.2024.102545},
      url          = {https://inrepo02.dkfz.de/record/288522},
}