%0 Journal Article
%A Debras, Charlotte
%A Cordova, Reynalda
%A Mayén, Ana-Lucia
%A Maasen, Kim
%A Knaze, Viktoria
%A Eussen, Simone Jpm
%A Schalkwijk, Casper G
%A Huybrechts, Inge
%A Tjønneland, Anne
%A Halkjær, Jytte
%A Katzke, Verena
%A Bajracharya, Rashmita
%A Schulze, Matthias B
%A Masala, Giovanna
%A Pala, Valeria
%A Pasanisi, Fabrizio
%A Macciotta, Alessandra
%A Petrova, Dafina
%A Castañeda, Jazmin
%A Santiuste, Carmen
%A Amiano, Pilar
%A Moreno-Iribas, Conchi
%A Borné, Yan
%A Sonestedt, Emily
%A Johansson, Ingegerd
%A Esberg, Anders
%A Aglago, Elom Kouassivi
%A Jenab, Mazda
%A Freisling, Heinz
%T Dietary intake of dicarbonyl compounds and changes in body weight over time in a large cohort of European adults.
%J British journal of nutrition
%V 131
%N 11
%@ 0007-1145
%C Cambridge
%I Cambridge University Press
%M DKFZ-2024-00396
%P 1902-1914
%D 2024
%Z 2024 Jun 14;131(11):1902-1914
%X Dicarbonyl compounds are highly reactive precursors of Advanced Glycation End-products (AGEs), produced endogenously, present in certain foods, and formed during food processing. AGEs contribute to development of adverse metabolic outcomes but health effects of dietary dicarbonyls are largely unexplored. We investigated associations between three dietary dicarbonyl compounds, methylglyoxal (MGO), glyoxal (GO), and 3-deoxyglucosone (3-DG), and body-weight changes in European adults. Dicarbonyl intakes were estimated using food composition database from 263,095 EPIC-PANACEA participants with two body-weight assessments (median follow-up time=5.4y). Associations between dicarbonyls and 5-year body-weight changes were estimated using mixed linear regression models. Stratified analyses by sex, age, and baseline BMI were performed. Risk of becoming overweight/obese was assessed using multivariable-adjusted logistic regression. MGO intake was associated with 5-year body-weight gain of 0.089kg (per 1-SD increase, 95
%K advanced glycation end products (Other)
%K body weight change (Other)
%K dietary dicarbonyl compounds (Other)
%K obesity (Other)
%K overweight (Other)
%K prospective cohort study (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:38383991
%R 10.1017/S0007114524000503
%U https://inrepo02.dkfz.de/record/288526