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000288526 041__ $$aEnglish
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000288526 1001_ $$00000-0002-0395-7161$$aDebras, Charlotte$$b0
000288526 245__ $$aDietary intake of dicarbonyl compounds and changes in body weight over time in a large cohort of European adults.
000288526 260__ $$aCambridge$$bCambridge University Press$$c2024
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000288526 500__ $$a2024 Jun 14;131(11):1902-1914
000288526 520__ $$aDicarbonyl compounds are highly reactive precursors of Advanced Glycation End-products (AGEs), produced endogenously, present in certain foods, and formed during food processing. AGEs contribute to development of adverse metabolic outcomes but health effects of dietary dicarbonyls are largely unexplored. We investigated associations between three dietary dicarbonyl compounds, methylglyoxal (MGO), glyoxal (GO), and 3-deoxyglucosone (3-DG), and body-weight changes in European adults. Dicarbonyl intakes were estimated using food composition database from 263,095 EPIC-PANACEA participants with two body-weight assessments (median follow-up time=5.4y). Associations between dicarbonyls and 5-year body-weight changes were estimated using mixed linear regression models. Stratified analyses by sex, age, and baseline BMI were performed. Risk of becoming overweight/obese was assessed using multivariable-adjusted logistic regression. MGO intake was associated with 5-year body-weight gain of 0.089kg (per 1-SD increase, 95%CI=0.072, 0.107). 3-DG was inversely associated with body-weight change (-0.076kg, -0.094, -0.058). No significant association was observed for GO (0.018kg, -0.002, 0.037). In stratified analyses, GO was associated with body-weight gain among women and older participants (above median of 52.4y). MGO was associated with higher body-weight gain among older participants. 3-DG was inversely associated with body-weight gain among younger and normal-weight participants. MGO was associated with higher risk of becoming overweight/obese, while inverse associations were observed for 3-DG. No associations were observed for GO with overweight/obesity. Dietary dicarbonyls are inconsistently associated with body-weight change among European adults. Further research is needed to clarify the role of these food components in overweight and obesity, their underlying mechanisms, and potential public-health implications.
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000288526 650_7 $$2Other$$aadvanced glycation end products
000288526 650_7 $$2Other$$abody weight change
000288526 650_7 $$2Other$$adietary dicarbonyl compounds
000288526 650_7 $$2Other$$aobesity
000288526 650_7 $$2Other$$aoverweight
000288526 650_7 $$2Other$$aprospective cohort study
000288526 7001_ $$aCordova, Reynalda$$b1
000288526 7001_ $$aMayén, Ana-Lucia$$b2
000288526 7001_ $$aMaasen, Kim$$b3
000288526 7001_ $$aKnaze, Viktoria$$b4
000288526 7001_ $$aEussen, Simone Jpm$$b5
000288526 7001_ $$00000-0003-0190-2690$$aSchalkwijk, Casper G$$b6
000288526 7001_ $$aHuybrechts, Inge$$b7
000288526 7001_ $$aTjønneland, Anne$$b8
000288526 7001_ $$aHalkjær, Jytte$$b9
000288526 7001_ $$0P:(DE-He78)fb68a9386399d72d84f7f34cfc6048b4$$aKatzke, Verena$$b10$$udkfz
000288526 7001_ $$0P:(DE-He78)0b48ce513fe49013263657450a12f870$$aBajracharya, Rashmita$$b11$$udkfz
000288526 7001_ $$aSchulze, Matthias B$$b12
000288526 7001_ $$aMasala, Giovanna$$b13
000288526 7001_ $$aPala, Valeria$$b14
000288526 7001_ $$aPasanisi, Fabrizio$$b15
000288526 7001_ $$aMacciotta, Alessandra$$b16
000288526 7001_ $$aPetrova, Dafina$$b17
000288526 7001_ $$aCastañeda, Jazmin$$b18
000288526 7001_ $$aSantiuste, Carmen$$b19
000288526 7001_ $$aAmiano, Pilar$$b20
000288526 7001_ $$aMoreno-Iribas, Conchi$$b21
000288526 7001_ $$aBorné, Yan$$b22
000288526 7001_ $$00000-0002-0747-4562$$aSonestedt, Emily$$b23
000288526 7001_ $$aJohansson, Ingegerd$$b24
000288526 7001_ $$aEsberg, Anders$$b25
000288526 7001_ $$aAglago, Elom Kouassivi$$b26
000288526 7001_ $$aJenab, Mazda$$b27
000288526 7001_ $$aFreisling, Heinz$$b28
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