TY  - JOUR
AU  - Debras, Charlotte
AU  - Cordova, Reynalda
AU  - Mayén, Ana-Lucia
AU  - Maasen, Kim
AU  - Knaze, Viktoria
AU  - Eussen, Simone Jpm
AU  - Schalkwijk, Casper G
AU  - Huybrechts, Inge
AU  - Tjønneland, Anne
AU  - Halkjær, Jytte
AU  - Katzke, Verena
AU  - Bajracharya, Rashmita
AU  - Schulze, Matthias B
AU  - Masala, Giovanna
AU  - Pala, Valeria
AU  - Pasanisi, Fabrizio
AU  - Macciotta, Alessandra
AU  - Petrova, Dafina
AU  - Castañeda, Jazmin
AU  - Santiuste, Carmen
AU  - Amiano, Pilar
AU  - Moreno-Iribas, Conchi
AU  - Borné, Yan
AU  - Sonestedt, Emily
AU  - Johansson, Ingegerd
AU  - Esberg, Anders
AU  - Aglago, Elom Kouassivi
AU  - Jenab, Mazda
AU  - Freisling, Heinz
TI  - Dietary intake of dicarbonyl compounds and changes in body weight over time in a large cohort of European adults.
JO  - British journal of nutrition
VL  - 131
IS  - 11
SN  - 0007-1145
CY  - Cambridge
PB  - Cambridge University Press
M1  - DKFZ-2024-00396
SP  - 1902-1914
PY  - 2024
N1  - 2024 Jun 14;131(11):1902-1914
AB  - Dicarbonyl compounds are highly reactive precursors of Advanced Glycation End-products (AGEs), produced endogenously, present in certain foods, and formed during food processing. AGEs contribute to development of adverse metabolic outcomes but health effects of dietary dicarbonyls are largely unexplored. We investigated associations between three dietary dicarbonyl compounds, methylglyoxal (MGO), glyoxal (GO), and 3-deoxyglucosone (3-DG), and body-weight changes in European adults. Dicarbonyl intakes were estimated using food composition database from 263,095 EPIC-PANACEA participants with two body-weight assessments (median follow-up time=5.4y). Associations between dicarbonyls and 5-year body-weight changes were estimated using mixed linear regression models. Stratified analyses by sex, age, and baseline BMI were performed. Risk of becoming overweight/obese was assessed using multivariable-adjusted logistic regression. MGO intake was associated with 5-year body-weight gain of 0.089kg (per 1-SD increase, 95
KW  - advanced glycation end products (Other)
KW  - body weight change (Other)
KW  - dietary dicarbonyl compounds (Other)
KW  - obesity (Other)
KW  - overweight (Other)
KW  - prospective cohort study (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:38383991
DO  - DOI:10.1017/S0007114524000503
UR  - https://inrepo02.dkfz.de/record/288526
ER  -