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@ARTICLE{Debras:288526,
      author       = {C. Debras and R. Cordova and A.-L. Mayén and K. Maasen and
                      V. Knaze and S. J. Eussen and C. G. Schalkwijk and I.
                      Huybrechts and A. Tjønneland and J. Halkjær and V.
                      Katzke$^*$ and R. Bajracharya$^*$ and M. B. Schulze and G.
                      Masala and V. Pala and F. Pasanisi and A. Macciotta and D.
                      Petrova and J. Castañeda and C. Santiuste and P. Amiano and
                      C. Moreno-Iribas and Y. Borné and E. Sonestedt and I.
                      Johansson and A. Esberg and E. K. Aglago and M. Jenab and H.
                      Freisling},
      title        = {{D}ietary intake of dicarbonyl compounds and changes in
                      body weight over time in a large cohort of {E}uropean
                      adults.},
      journal      = {British journal of nutrition},
      volume       = {131},
      number       = {11},
      issn         = {0007-1145},
      address      = {Cambridge},
      publisher    = {Cambridge University Press},
      reportid     = {DKFZ-2024-00396},
      pages        = {1902-1914},
      year         = {2024},
      note         = {2024 Jun 14;131(11):1902-1914},
      abstract     = {Dicarbonyl compounds are highly reactive precursors of
                      Advanced Glycation End-products (AGEs), produced
                      endogenously, present in certain foods, and formed during
                      food processing. AGEs contribute to development of adverse
                      metabolic outcomes but health effects of dietary dicarbonyls
                      are largely unexplored. We investigated associations between
                      three dietary dicarbonyl compounds, methylglyoxal (MGO),
                      glyoxal (GO), and 3-deoxyglucosone (3-DG), and body-weight
                      changes in European adults. Dicarbonyl intakes were
                      estimated using food composition database from 263,095
                      EPIC-PANACEA participants with two body-weight assessments
                      (median follow-up time=5.4y). Associations between
                      dicarbonyls and 5-year body-weight changes were estimated
                      using mixed linear regression models. Stratified analyses by
                      sex, age, and baseline BMI were performed. Risk of becoming
                      overweight/obese was assessed using multivariable-adjusted
                      logistic regression. MGO intake was associated with 5-year
                      body-weight gain of 0.089kg (per 1-SD increase,
                      $95\%CI=0.072,$ 0.107). 3-DG was inversely associated with
                      body-weight change (-0.076kg, -0.094, -0.058). No
                      significant association was observed for GO (0.018kg,
                      -0.002, 0.037). In stratified analyses, GO was associated
                      with body-weight gain among women and older participants
                      (above median of 52.4y). MGO was associated with higher
                      body-weight gain among older participants. 3-DG was
                      inversely associated with body-weight gain among younger and
                      normal-weight participants. MGO was associated with higher
                      risk of becoming overweight/obese, while inverse
                      associations were observed for 3-DG. No associations were
                      observed for GO with overweight/obesity. Dietary dicarbonyls
                      are inconsistently associated with body-weight change among
                      European adults. Further research is needed to clarify the
                      role of these food components in overweight and obesity,
                      their underlying mechanisms, and potential public-health
                      implications.},
      keywords     = {advanced glycation end products (Other) / body weight
                      change (Other) / dietary dicarbonyl compounds (Other) /
                      obesity (Other) / overweight (Other) / prospective cohort
                      study (Other)},
      cin          = {C020},
      ddc          = {570},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:38383991},
      doi          = {10.1017/S0007114524000503},
      url          = {https://inrepo02.dkfz.de/record/288526},
}