000288534 001__ 288534
000288534 005__ 20241114135115.0
000288534 0247_ $$2doi$$a10.1038/s41467-024-45645-w
000288534 0247_ $$2pmid$$apmid:38360885
000288534 0247_ $$2pmc$$apmc:PMC10869706
000288534 0247_ $$2altmetric$$aaltmetric:159539865
000288534 037__ $$aDKFZ-2024-00398
000288534 041__ $$aEnglish
000288534 082__ $$a500
000288534 1001_ $$aMinoia, Melania$$b0
000288534 245__ $$aChp1 is a dedicated chaperone at the ribosome that safeguards eEF1A biogenesis.
000288534 260__ $$a[London]$$bNature Publishing Group UK$$c2024
000288534 3367_ $$2DRIVER$$aarticle
000288534 3367_ $$2DataCite$$aOutput Types/Journal article
000288534 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1708701151_2949
000288534 3367_ $$2BibTeX$$aARTICLE
000288534 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000288534 3367_ $$00$$2EndNote$$aJournal Article
000288534 500__ $$aDKFZ-ZMBH Alliance
000288534 520__ $$aCotranslational protein folding depends on general chaperones that engage highly diverse nascent chains at the ribosomes. Here we discover a dedicated ribosome-associated chaperone, Chp1, that rewires the cotranslational folding machinery to assist in the challenging biogenesis of abundantly expressed eukaryotic translation elongation factor 1A (eEF1A). Our results indicate that during eEF1A synthesis, Chp1 is recruited to the ribosome with the help of the nascent polypeptide-associated complex (NAC), where it safeguards eEF1A biogenesis. Aberrant eEF1A production in the absence of Chp1 triggers instant proteolysis, widespread protein aggregation, activation of Hsf1 stress transcription and compromises cellular fitness. The expression of pathogenic eEF1A2 variants linked to epileptic-dyskinetic encephalopathy is protected by Chp1. Thus, eEF1A is a difficult-to-fold protein that necessitates a biogenesis pathway starting with dedicated folding factor Chp1 at the ribosome to protect the eukaryotic cell from proteostasis collapse.
000288534 536__ $$0G:(DE-HGF)POF4-311$$a311 - Zellbiologie und Tumorbiologie (POF4-311)$$cPOF4-311$$fPOF IV$$x0
000288534 588__ $$aDataset connected to CrossRef, PubMed, , Journals: inrepo02.dkfz.de
000288534 650_2 $$2MeSH$$aRibosomes: genetics
000288534 650_2 $$2MeSH$$aRibosomes: metabolism
000288534 650_2 $$2MeSH$$aProtein Folding
000288534 650_2 $$2MeSH$$aProteostasis
000288534 650_2 $$2MeSH$$aEukaryotic Cells: metabolism
000288534 650_2 $$2MeSH$$aProtein Biosynthesis
000288534 7001_ $$00000-0002-8234-2922$$aQuintana-Cordero, Jany$$b1
000288534 7001_ $$0P:(DE-He78)78f370420b01b525317f9372dbd4d78f$$aJetzinger, Katharina$$b2
000288534 7001_ $$00000-0001-9028-979X$$aKotan, Ilgin Eser$$b3
000288534 7001_ $$00000-0002-0899-974X$$aTurnbull, Kathryn Jane$$b4
000288534 7001_ $$aCiccarelli, Michela$$b5
000288534 7001_ $$aMasser, Anna E$$b6
000288534 7001_ $$aLiebers, Dorina$$b7
000288534 7001_ $$aGouarin, Eloïse$$b8
000288534 7001_ $$aCzech, Marius$$b9
000288534 7001_ $$00000-0003-2389-5057$$aHauryliuk, Vasili$$b10
000288534 7001_ $$0P:(DE-He78)9d539bc25fa8f4ff093b6f6e10d39476$$aBukau, Bernd$$b11$$udkfz
000288534 7001_ $$0P:(DE-He78)8b9aa336210db1592efa7400628e5a46$$aKramer, Günter$$b12$$udkfz
000288534 7001_ $$00000-0001-8948-0685$$aAndréasson, Claes$$b13
000288534 773__ $$0PERI:(DE-600)2553671-0$$a10.1038/s41467-024-45645-w$$gVol. 15, no. 1, p. 1382$$n1$$p1382$$tNature Communications$$v15$$x2041-1723$$y2024
000288534 8564_ $$uhttps://inrepo02.dkfz.de/record/288534/files/s41467-024-45645-w.pdf
000288534 8564_ $$uhttps://inrepo02.dkfz.de/record/288534/files/s41467-024-45645-w.pdf?subformat=pdfa$$xpdfa
000288534 909CO $$ooai:inrepo02.dkfz.de:288534$$pVDB
000288534 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)78f370420b01b525317f9372dbd4d78f$$aDeutsches Krebsforschungszentrum$$b2$$kDKFZ
000288534 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)9d539bc25fa8f4ff093b6f6e10d39476$$aDeutsches Krebsforschungszentrum$$b11$$kDKFZ
000288534 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)8b9aa336210db1592efa7400628e5a46$$aDeutsches Krebsforschungszentrum$$b12$$kDKFZ
000288534 9131_ $$0G:(DE-HGF)POF4-311$$1G:(DE-HGF)POF4-310$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lKrebsforschung$$vZellbiologie und Tumorbiologie$$x0
000288534 9141_ $$y2024
000288534 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bNAT COMMUN : 2022$$d2023-08-29
000288534 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2023-08-29
000288534 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2023-08-29
000288534 915__ $$0StatID:(DE-HGF)0320$$2StatID$$aDBCoverage$$bPubMed Central$$d2023-08-29
000288534 915__ $$0StatID:(DE-HGF)0501$$2StatID$$aDBCoverage$$bDOAJ Seal$$d2023-05-02T09:09:09Z
000288534 915__ $$0StatID:(DE-HGF)0500$$2StatID$$aDBCoverage$$bDOAJ$$d2023-05-02T09:09:09Z
000288534 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bDOAJ : Peer review$$d2023-05-02T09:09:09Z
000288534 915__ $$0LIC:(DE-HGF)CCBYNV$$2V:(DE-HGF)$$aCreative Commons Attribution CC BY (No Version)$$bDOAJ$$d2023-05-02T09:09:09Z
000288534 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2023-08-29
000288534 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews$$d2023-08-29
000288534 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2023-08-29
000288534 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2023-08-29
000288534 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences$$d2023-08-29
000288534 915__ $$0StatID:(DE-HGF)1190$$2StatID$$aDBCoverage$$bBiological Abstracts$$d2023-08-29
000288534 915__ $$0StatID:(DE-HGF)1060$$2StatID$$aDBCoverage$$bCurrent Contents - Agriculture, Biology and Environmental Sciences$$d2023-08-29
000288534 915__ $$0StatID:(DE-HGF)1040$$2StatID$$aDBCoverage$$bZoological Record$$d2023-08-29
000288534 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2023-08-29
000288534 915__ $$0StatID:(DE-HGF)1150$$2StatID$$aDBCoverage$$bCurrent Contents - Physical, Chemical and Earth Sciences$$d2023-08-29
000288534 915__ $$0StatID:(DE-HGF)9915$$2StatID$$aIF >= 15$$bNAT COMMUN : 2022$$d2023-08-29
000288534 915__ $$0StatID:(DE-HGF)0561$$2StatID$$aArticle Processing Charges$$d2023-08-29
000288534 915__ $$0StatID:(DE-HGF)0700$$2StatID$$aFees$$d2023-08-29
000288534 9201_ $$0I:(DE-He78)A250-20160331$$kA250$$lA250 Chaperone und Proteasen$$x0
000288534 980__ $$ajournal
000288534 980__ $$aVDB
000288534 980__ $$aI:(DE-He78)A250-20160331
000288534 980__ $$aUNRESTRICTED