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@ARTICLE{Salwender:288715,
      author       = {H. Salwender and N. Weinhold and A. Benner$^*$ and K.
                      Miah$^*$ and M. Merz and M. Haenel and C. Jehn and E. Mai
                      and E. Menis and I. Blau and C. Scheid and D. Hose and A.
                      Seckinger and S. Luntz and B. Besemer and M. Munder and P.
                      Brossart and B. Glass and H.-W. Lindemann and K. Weisel and
                      C. Hanoun and P. Schnitzler and S. Klemm and H. Goldschmidt
                      and M. Raab and A. Elmaagacli},
      title        = {{C}ytomegalovirus immunoglobulin serology prevalence in
                      patients with newly diagnosed multiple myeloma treated
                      within the {GMMG}-{MM}5 phase {III} trial.},
      journal      = {Hematology},
      volume       = {29},
      number       = {1},
      issn         = {1024-5332},
      address      = {Abingdon, Oxon},
      publisher    = {Taylor $\&$ Francis},
      reportid     = {DKFZ-2024-00434},
      pages        = {2320006},
      year         = {2024},
      abstract     = {The seroprevalence of antibodies against Cytomegalovirus
                      (CMV) is an established poor prognostic factor for patients
                      receiving an allogeneic stem cell transplantation. However,
                      the impact of CMV serology on outcome after autologous stem
                      cell transplantation remains unknown.Here, we analyzed the
                      CMV immunoglobulin (Ig) serology of 446 newly-diagnosed
                      multiple myeloma (MM) patients of the GMMG-MM5 phase III
                      trial with a median follow-up of 58 months.CMV IgG and IgM
                      positivity was seen in $51\%$ and $6\%$ of the patients,
                      respectively. In multivariate analysis CMV IgG and CMV IgM
                      serology show an age-depending effect for PFS. We identified
                      positive CMV IgG/positive CMV IgM serology as an
                      age-depending beneficial factor on PFS.Younger patients with
                      a positive CMV IgG/positive CMV IgM serology experienced a
                      favorable effect on PFS, whereas a positive CMV IgG/positive
                      CMV IgM serology at older age has a disadvantageous effect
                      on PFS.},
      keywords     = {Humans / Cytomegalovirus / Hematopoietic Stem Cell
                      Transplantation / Multiple Myeloma: diagnosis / Multiple
                      Myeloma: therapy / Prevalence / Seroepidemiologic Studies /
                      Transplantation, Autologous / Immunoglobulins, Intravenous /
                      Antibodies, Viral / Immunoglobulin G / Cytomegalovirus
                      Infections: epidemiology / Immunoglobulin M / CMV (Other) /
                      CMV IgM (Other) / CMV-Infection (Other) / GMMG-MM5 Phase III
                      Trial (Other) / age-depending effect (Other) / autologous
                      stem cell transplantation (Other) / maintenance therapy
                      (Other) / multiple myeloma (Other) /
                      cytomegalovirus-specific hyperimmune globulin (NLM
                      Chemicals) / Immunoglobulins, Intravenous (NLM Chemicals) /
                      Antibodies, Viral (NLM Chemicals) / Immunoglobulin G (NLM
                      Chemicals) / Immunoglobulin M (NLM Chemicals)},
      cin          = {C060},
      ddc          = {610},
      cid          = {I:(DE-He78)C060-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:38407192},
      doi          = {10.1080/16078454.2024.2320006},
      url          = {https://inrepo02.dkfz.de/record/288715},
}