%0 Journal Article
%A Decker, Nina Sophia
%A Johnson, Theron
%A Le Cornet, Charlotte
%A Behrens, Sabine
%A Obi, Nadia
%A Kaaks, Rudolf
%A Chang-Claude, Jenny
%A Fortner, Renée Turzanski
%T Associations between lifestyle, health, and clinical characteristics and circulating oxysterols and cholesterol precursors in women diagnosed with breast cancer: a cross-sectional study.
%J Scientific reports
%V 14
%N 1
%@ 2045-2322
%C [London]
%I Macmillan Publishers Limited, part of Springer Nature
%M DKFZ-2024-00477
%P 4977
%D 2024
%Z #EA:C020#LA:C020#
%X Despite increasing evidence that cholesterol precursors and oxysterols, oxidized cholesterol metabolites, play a role in numerous pathological processes and diseases including breast cancer, little is known about correlates of these sterols in women with breast cancer. In this study, 2282 women with breast cancer and blood draw post diagnosis were included and cross-sectional associations between circulating levels of 15 sterols/oxysterols and (a) lifestyle, anthropometric, reproductive characteristics, (b) comorbidities and medication use, and (c) breast cancer tumor and treatment characteristics were calculated using generalized linear models. Obesity was strongly associated with circulating levels of 7-dehydrocholesterol (DC) (body mass index ≥ 30 vs. 18.5-24.9 kg/m2: 51.7
%K Humans
%K Female
%K Oxysterols: metabolism
%K Cross-Sectional Studies
%K Breast Neoplasms: metabolism
%K Cholesterol: metabolism
%K Sterols
%K Phytosterols
%K Life Style
%K Oxysterols (NLM Chemicals)
%K Cholesterol (NLM Chemicals)
%K Sterols (NLM Chemicals)
%K Phytosterols (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:38424253
%2 pmc:PMC10904394
%R 10.1038/s41598-024-55316-x
%U https://inrepo02.dkfz.de/record/288794