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000288794 1001_ $$0P:(DE-He78)8224c4651852c416fc2613e1307597c2$$aDecker, Nina Sophia$$b0$$eFirst author$$udkfz
000288794 245__ $$aAssociations between lifestyle, health, and clinical characteristics and circulating oxysterols and cholesterol precursors in women diagnosed with breast cancer: a cross-sectional study.
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000288794 520__ $$aDespite increasing evidence that cholesterol precursors and oxysterols, oxidized cholesterol metabolites, play a role in numerous pathological processes and diseases including breast cancer, little is known about correlates of these sterols in women with breast cancer. In this study, 2282 women with breast cancer and blood draw post diagnosis were included and cross-sectional associations between circulating levels of 15 sterols/oxysterols and (a) lifestyle, anthropometric, reproductive characteristics, (b) comorbidities and medication use, and (c) breast cancer tumor and treatment characteristics were calculated using generalized linear models. Obesity was strongly associated with circulating levels of 7-dehydrocholesterol (DC) (body mass index ≥ 30 vs. 18.5-24.9 kg/m2: 51.7% difference) and 7-ketocholesterol (KC) (40.0% difference). After adjustment for BMI, comorbidities such as cardiovascular disease were associated with higher levels of 7-DC (26.1% difference) and lower levels of desmosterol (- 16.4% difference). Breast cancer tumor characteristics including hormone receptor status, tumor stage, and endocrine therapy were associated with lanosterol, 24-DHLan, 7b-HC, and THC (e.g., THC; tumor stage IIIa vs. I: 36.9% difference). Weaker associations were observed for lifestyle characteristics and for any of the other oxysterols. The findings of this study suggest that cholesterol precursors are strongly associated with metabolic factors, while oxysterols are associated with breast cancer tumor characteristics, warranting further investigation into the role of cholesterol precursors and oxysterols in women with breast cancer and other populations.
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000288794 650_7 $$2NLM Chemicals$$aOxysterols
000288794 650_7 $$097C5T2UQ7J$$2NLM Chemicals$$aCholesterol
000288794 650_7 $$2NLM Chemicals$$aSterols
000288794 650_7 $$2NLM Chemicals$$aPhytosterols
000288794 650_2 $$2MeSH$$aHumans
000288794 650_2 $$2MeSH$$aFemale
000288794 650_2 $$2MeSH$$aOxysterols: metabolism
000288794 650_2 $$2MeSH$$aCross-Sectional Studies
000288794 650_2 $$2MeSH$$aBreast Neoplasms: metabolism
000288794 650_2 $$2MeSH$$aCholesterol: metabolism
000288794 650_2 $$2MeSH$$aSterols
000288794 650_2 $$2MeSH$$aPhytosterols
000288794 650_2 $$2MeSH$$aLife Style
000288794 7001_ $$0P:(DE-He78)79ab945544e5bc017a2317b6146ed3aa$$aJohnson, Theron$$b1$$udkfz
000288794 7001_ $$0P:(DE-He78)2d4cac0f4bf270325b98fe07036dc6c6$$aLe Cornet, Charlotte$$b2$$udkfz
000288794 7001_ $$0P:(DE-He78)6b04712f3afe72044d496a25505cb1ea$$aBehrens, Sabine$$b3$$udkfz
000288794 7001_ $$aObi, Nadia$$b4
000288794 7001_ $$0P:(DE-He78)4b2dc91c9d1ac33a1c0e0777d0c1697a$$aKaaks, Rudolf$$b5$$udkfz
000288794 7001_ $$0P:(DE-He78)c259d6cc99edf5c7bc7ce22c7f87c253$$aChang-Claude, Jenny$$b6$$udkfz
000288794 7001_ $$0P:(DE-He78)74a6af8347ec5cbd4b77e562e10ca1f2$$aFortner, Renée Turzanski$$b7$$eLast author$$udkfz
000288794 773__ $$0PERI:(DE-600)2615211-3$$a10.1038/s41598-024-55316-x$$gVol. 14, no. 1, p. 4977$$n1$$p4977$$tScientific reports$$v14$$x2045-2322$$y2024
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